Since the BIN’s inception in 2016, its scientists have published the results of their research in numerous scientific journals.

Year of the publications


  • Erdmann L, Santos PI, Rieper P, Klafki HW, Beutner D, Wiltfang J, Outeiro TF, Setz C.
    Automated Capillary Electrophoresis Immunoblot for the Detection of Alpha-Synuclein in Mouse Tissue.
    J Parkinsons Dis. 2024 Apr 5. doi: 10.3233/JPD-230379. Online ahead of print. PMID: 38578903. (PubMed)
  • Outeiro TF, Kalia LV, Bezard E, Ferrario J, Lin CH, Salama M, Standaert DG, Taiwo L, Takahashi R, Vila M, Mollenhauer B, Svenningsson P; MDS Basic Science Special Interest Group Steering Committee.
    Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice
    Mov Disord. 2024 Apr 4. doi: 10.1002/mds.29802. Online ahead of print. PMID: 38576081. (PubMed)
  • Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A Jr, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J, Moser T.
    Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.
    Protein Cell. 2024 2024 Apr 1;15(4):305-312. doi: 10.1093/procel/pwad058. PMID: 38066594. (PubMed)
  • Unterauer EM, Boushehri SS, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, Opazo F, Fornasiero EF, Jungmann R.
    Spatial proteomics in neurons at single-protein resolution.
    Cell 2024 Mar 28;187(7):1785-1800.e16. doi: 10.1016/j.cell.2024.02.045 PMID: 38552614. (PubMed)
  • Bosbach C, Gatzemeier LM, Bloch von Blottnitz KI, König A, Diederichsen U, Steinem C, Outeiro TF.
    Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments.
    Org Biomol Chem. 2024 Mar 27;22(13):2670-2676. doi: 10.1039/d4ob00225c. PMID: 38483440. (PubMed)
  • Plácido E, Koss DJ, Outeiro TF, Brocardo PS.
    Altered hippocampal doublecortin expression in Parkinson's disease.
    J Neurochem. 2024 Mar 14. doi: 10.1111/jnc.16101. Online ahead of print. PMID: 38485468. (PubMed)
  • Chopra A, Lang AE, Höglinger G, Outeiro TF.
    Towards a biological diagnosis of PD.
    Review Parkinsonism Relat Disord. 2024 Mar 6:106078.doi: 10.1016/j.parkreldis.2024.106078. Online ahead of print. PMID: 38472075. (PubMed)
  • Rubilar JC, Outeiro TF, Klein AD.
    The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson's therapeutics.
    Brain 2024 Mar 4:awae070. doi: 10.1093/brain/awae070. Online ahead of print. PMID: 38437875. (PubMed)
  • da Silva ANR, Pereira GRC, Bonet LFS, Outeiro TF, De Mesquita JF.
    In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease.
    J Cell Biochem. 2024 Mar;125(3):e30523. doi: 10.1002/jcb.30523. Epub 2024 Jan 18. PMID: 38239037. (PubMed)
  • Alsouri S, Ambrose A, Mougios N, Paglilla N, Mayr F, Choi K, Loeber J, Chapuy B, Haeupl B, Opazo F, Oellerich T, Gold M, Engelke M.
    Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors.
    Immunol. 2024 Mar;54(3):e2350774. doi: 10.1002/eji.202350774. Epub 2024 Feb 1 PMID: 38299456. (PubMed)
  • Tatenhorst L, Maass F, Paul F, Dambeck V, Bähr M, Dono R, Lingor P.
    Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.
    Sci Rep. 2024 Feb 29;14(1):5005. doi: 10.1038/s41598-024-54800-8. PMID: 38424123. (PubMed)
  • Galka D, Ali TT, Bast A, Niederleithinger M, Gerhardt E, Motosugi R, Sakata E, Knop M, Outeiro TF, Popova B, Braus GH.
    Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1.
    Aging Cell. 2024 Feb 28:e14128. doi: 10.1111/acel.14128. Online ahead of print. PMID: 38415292. (PubMed)
  • Malik N, Miah MU, Galgani A, McAleese K, Walker L, LeBeau FE, Attems J, Outeiro TF, Thomas A, Koss DJ.
    Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change.
    Acta Neuropathol. 2024 Feb 14;147(1):40. doi: 10.1007/s00401-024-02691-4. PMID: 38353753. (PubMed)
  • Höglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE.
    A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria.
    Lancet Neurol. 2024 Feb;23(2):191-204. doi: 10.1016/S1474-4422(23)00404-0. PMID: 38267191. (PubMed)
  • Quesnel A, Martin LD, Tarzi C, Lenis VP, Coles N, Islam M, Angione C, Outeiro TF, Khundakar AA, Filippou PS.
    Uncovering potential diagnostic and pathophysiological roles of α-synuclein and DJ-1 in melanoma.
    Cancer Med. 2024 Jan 8;13(1):e6900. doi: 10.1002/cam4.6900. Online ahead of print. PMID: 38189631. (PubMed)
  • Aubrey LD, Ninkina N, Ulamec SM, Abramycheva NY, Vasili E, Devine OM, Wilkinson M, Mackinnon E, Limorenko G, Walko M, Muwanga S, Amadio L, Peters OM, Illarioshkin SN, Outeiro TF, Ranson NA, Brockwell DJ, Buchman VL, Radford SE.
    Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
    Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309700120. doi: 10.1073/pnas.2309700120. Epub 2024 Jan 3. PMID: 38170745. (PubMed)
  • Chopra A, Outeiro TF.
    Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies.
    Brain. 2024 Jan 4;147(1):81-90. doi: 10.1093/brain/awad260. PMID: 37526295. (PubMed)
  • DʼEste E, Lukinavičius G, Lincoln R, Opazo F, Fornasiero EF.
    Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations.
    Trends Cell Biol. 2024 Jan 5:S0962-8924(23)00239-8.doi: 10.1016/j.tcb.2023.12.001. Online ahead of print. PMID: 38184400. (PubMed)


  • de Jong-Bolm D, Sadeghi M, Bogaciu CA, Bao G, Klaehn G, Hoff M, Mittelmeier L, Basmanav FB, Opazo F, Noé F, Rizzoli SO.
    Protein nanobarcodes enable single-step multiplexed fluorescence imaging.
    PLOS Biol. 2023 Dec 11;21(12):e3002427.doi: 10.1371/journal.pbio.3002427. eCollection 2023 Dec. PMID: 38079451. (PubMed)
  • Hintze A, Lange F, Steyer AM, Anstatt J, Möbius W, Jakobs S, Wichmann C.
    Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus.
    iScience. 2023 Dec 8;27(1):108700. doi: 10.1016/j.isci.2023.108700. eCollection 2024 Jan 19. PMID: 38213623. (PubMed)
  • Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA.
    Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis.
    Biochim Biophys Acta Mol Basis Dis. 2023 Dec;1869(8):166835. doi: 10.1016/j.bbadis.2023.166835. Epub 2023 Aug 7. PMID: 37558009. (PubMed)
  • Alexander LT et al.
    Protein target highlights in CASP15: Analysis of models by structure providers.
    Proteins. 2023 Dec;91(12):1571-1599.doi: 10.1002/prot.26545. Epub 2023 Jul 26. PMID: 37493353. (PubMed)
  • Vieira TCRG, Barros CA, Domingues R, Outeiro TF.
    PrP meets alpha-synuclein: Molecular mechanisms and implications for disease.
    J Neurochem. 2023 Oct 19. doi: 10.1111/jnc.15992. Online ahead of print. PMID: 37855859. (PubMed)
  • Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO.
    High-resolution analysis of bound Ca2+ in neurons and synapses.
    Life Sci Alliance. 2023 Oct 13;7(1):e202302030. doi: 10.26508/lsa.202302030. Print 2024 Jan. PMID: 37833073. (PubMed)
  • Klein AD, Outeiro TF.
    Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria.
    Nat Commun. 2023 Oct 11;14(1):6383. doi: 10.1038/s41467-023-42107-7. PMID: 37821433. (PubMed)
  • Real KQZV, Mougios N, Rehm R, Sograte-Idrissi S , Albert L , Rahimi AM, Maidorn M, Hentze J , Martínez-Carranza M , Hosseini H, Saal KA, Oleksiievets N, Prigge M, Tsukanov R, Stenmark P, Fornasiero EF, Opazo F.
    A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy.
    Small Methods. 2023 Oct;7(10):e2300218.doi: 10.1002/smtd.202300218. Epub 2023 Jul 8. PMID: 37421204. (PubMed)
  • Michanski S, Kapoor R*, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra KF, Neef J, Strenzke N, Moser T, Wichmann C.
    Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
    EMBO Rep. 2023 Sep 6;24(9):e56702. doi: 10.15252/embr.202256702. Epub 2023 Jul 21. PMID: 37477166. (PubMed)
  • Hune TLK, Mamone S, Schmidt AB, Mahú I, D’Apolito N, Wiedermann D, Brüning J, Glöggler S.
    Hyperpolarized Multi-organ Spectroscopy of Liver and Brain Using 1-13C-Pyruvate Enhjanced via Parahydrogen.
    Appl. Magn. Reson. doi: 10.1007/s00723-023-01578-z (2023). (ResearchSquare)
  • de Maissin H, Groß PR, Mohiuddin O, Weigt M, Nagel L, Herzog M, Wang Z, Willing R, Reichardt W, Pichotka M, Heß L, Reinheckel T, Jessen HJ, Zeiser R, Bock M, von Elverfeldt D, Zaitsev M, Korchak S, Glöggler S, Hövener JB, Chekmenev EY, Schilling F, Knecht S, Schmidt AB.
    In Vivo Metabolic Imaging of [1-13 C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen.
    Angew. Chem. Int. Ed. Engl. 2023 Sep 4;62(36):e202306654. doi: 10.1002/anie.202306654. Epub 2023 Jul 25. . PMID: 37439488. (PubMed)
  • Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP.
    Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
    J Neurochem. 2023 Sep 3. doi: 10.1111/jnc.15956. Online ahead of print. PMID: 37661637. (PubMed)
  • Flores-Leon M, Outeiro TF.
    More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy.
    Acta Neuropathol. 2023 Sep;146(3):369-385. doi: 10.1007/s00401-023-02601-0. Epub 2023 Jul 8. PMID: 37236414. (PubMed)
  • Georgiev SV, Rizzoli SO.
    The long-loop recycling (LLR) of synaptic components as a question of economics.
    Mol Cell Neurosci. 2023 Sep:126:103862. doi: 10.1016/j.mcn.2023.103862 PMID: 37236414. (PubMed)
  • Xylaki M, Chopra A, Weber S, Bartl M, Outeiro TF, Mollenhauer B.
    Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis.
    Mov Disord. 2023 Sep;38(9):1585-1597. doi: 10.1002/mds.29497. Epub 2023 Jul 14. PMID: 37449706. (PubMed)
  • Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M,Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P.
    Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.
    J Neurochem. 2023 Sep;166(5):862-874. doi: 10.1111/jnc.15924. Epub 2023 Jul 28. PMID: 37515330. (PubMed)
  • Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A.
    Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson's Disease.
    Int J Mol Sci. 2023 Aug 30;24(17):13435. doi: 10.3390/ijms241713435. PMID: 37686236. (PubMed)
  • Sant'Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D.
    The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.
    Mol Med. 2023 Aug 18;29(1):111. doi: 10.1186/s10020-023-00704-8. PMID: 37596531. (PubMed)
  • Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi-Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C.
    Age-dependent structural reorganization of utricular ribbon synapses.
    Front Cell Dev Biol. 2023 Aug 10:11:1178992.doi: 10.3389/fcell.2023.1178992. eCollection 2023. PMID: 37635868. (PubMed)
  • Plácido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS.
    Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington's Disease Effects in YAC128 Mice.
    Int J Mol Sci. 2023 Aug 9;24(16):12607. doi: 10.3390/ijms241612607. PMID: 37628801. (PubMed)
  • Outeiro TF, Vieira TCRG.
    AI and protein structure and function in neurological disease: relevance to disease management.
    Nat Rev Neurol. 2023 Aug;19(8):453-454. doi: 10.1038/s41582-023-00840-z. PMID: 37394622. (PubMed)
  • Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP.
    Targeting Biomolecular Condensation and Protein Aggregation against Cancer.
    Chem Rev. 2023 Jul 26;123(14):9094-9138. doi: 10.1021/acs.chemrev.3c00131. Epub 2023 Jun 28. PMID: 37379327. (PubMed)
  • Zhang S, Dauer K, Strohäker T, Tatenhorst L, Caldi Gomes L, Mayer S , Jung BC , Kim WS, Lee SJ, Becker S, Liesche-Starnecker F, Zweckstetter M, Lingor P.
    Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.
    Brain Pathol. 2023 Jul 24. doi: 10.1111/bpa.13196. Online ahead of print. PMID: 37485772. (PubMed)
  • Peifer M, Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F.
    Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.
    Mol Biol Cell. 2023 Jul 1;34(8):ar81. doi: 10.1091/mbc.E23-03-0077. Epub 2023 May 10. PMID: 37163320. (PubMed)
  • Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP.
    Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease.
    J Neurochem. 2023 Jun 28.doi: 10.1111/jnc.15890. Online ahead of print. PMID: 37381043. (PubMed)
  • Ding Y, Stevanato G, von Bonin F, Kube D, Glöggler S.
    Real-time cell metabolism assessed repeatedly on the same cells via para-hydrogen induced polarization.
    Chem. Sci. 2023 Jun 20;14(28):7642-7647. doi: 10.1039/d3sc01350b. eCollection 2023 Jul 19. PMID: 37476713. (PubMed)
  • Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF.
    Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation.
    Chemistry. 2023 Jun 13;29(33):e202300649.doi: 10.1002/chem.202300649. Epub 2023 Apr 27. PMID: 36971510. (PubMed)
  • Gelain DP, Bittencourt RR, Bastos Mendes LF, Moreira JCF, Outeiro TF.
    RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.
    J Parkinsons Dis. 2023; May 31.doi: 10.3233/JPD-230070. Online ahead of print. PMID: 37270812. (PubMed)
  • Domingos J, Teixeira Bastos MDC, Couto R, Cameira AR, Cardoso AL, Reffóios A, Magalhães S, Massano J, Outeiro TF.
    People with Early Onset Parkinson's Disease: Empowered to Improve Care.
    J Parkinsons Dis. 2023 13(4):633-636.doi: 10.3233/JPD-230039. PMID: 37182901. (PubMed)
  • Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ.
    Defining the Riddle in Order to Solve It: There Is More Than One "Parkinson's Disease" .
    Mov Disord. 2023 May 8.doi: 10.1002/mds.29419. Online ahead of print. PMID: 37156737. (PubMed)
  • Hosang L, Löhndorf A, Dohle W, Rosche A, Marry S, Diercks B-P, Müller-Kirschbaum LC, Flügel LT, Potter BVL, Odoardi F, Guse AH, Flügel A.
    2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.
    Biochim Biophys Acta Mol Cell Res. 2023 Aug;1870(6):119485. doi: 10.1016/j.bbamcr.2023.119485. Epub 2023 May 6. . PMID: 37150482. (PubMed)
  • Kilisch M, Gere-Becker M, Wüstefeld L, Bonnas C, Crauel A , Mechmershausen M, Martens H, Götzke H, Opazo F, Frey S.
    Simple and Highly Efficient Detection of PSD95 Using a Nanobody and Its Recombinant Heavy-Chain Antibody Derivatives.
    Int J Mol Sci. 2023 Apr 14;24(8):7294.doi: 10.3390/ijms24087294. PMID: 37108454. (PubMed)
  • Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN.
    Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
    Nat Commun. 2023 Apr 6;14(1):1918. doi: 10.1038/s41467-023-37561-2. PMID: 37024503. (PubMed)
  • Hülskötter K, Lühder F, Leitzen E, Flügel A, Baumgärtner W.
    CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis.
    Front Immunol. 2023 Apr 5;14:1105432. doi: 10.3389/fimmu.2023.1105432. eCollection 2023. PMID: 37090733. (PubMed)
  • Saal KA, Shaib AH, Mougios N , Crzan D, Opazo F, Rizzoli SO.
    Heat denaturation enables multicolor X10-STED microscopy.
    Sci Rep. 2023 Apr 1;13(1):5366. doi: 10.1038/s41598-023-32524-5. PMID: 37005431. (PubMed)
  • Stevanato G, Ding Y, Mamone S, Jagtap A, Korchak S, Glöggler S.
    Real-Time Pyruvate Chemical Conversion Monitoring Enabled by PHIP.
    J. Am. Chem. Soc. 2023 Mar 15;145(10):5864-5871. doi: 10.1021/jacs.2c13198. Epub 2023 Mar 1 . PMID: 36857108. (PubMed)
  • Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V.
    Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation.
    Cells. 2023 Mar 6;12(5):818. doi: 10.3390/cells12050818. PMID: 36899953. (PubMed)
  • Quesnel A, Coles N, Angione C, Dey P, Polvikoski TM, Outeiro TF, Islam M, Khundakar AA, Filippou PS.
    Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy.
    BMC Cancer. 2023 Feb 21;23(1):174.doi: 10.1186/s12885-023-10588-w. PMID: 36809974. (PubMed)
  • Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF.
    miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.
    J Parkinsons Dis. 2023; 13(2):179-196. doi: 10.3233/JPD-225055. PMID: 36744345. (PubMed)
  • Shvachiy L, Geraldes V, Outeiro TF.
    Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease.
    Antioxid Redox Signal. 2023 Mar 6. doi: 10.1089/ars.2022.0076. Online ahead of print. PMID: 36641635. (PubMed)
  • Marsili L, Sharma J, Outeiro TF, Colosimo C.
    Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials.
    Biomedicines. 2023 Feb 9;11(2):505. doi: 10.3390/biomedicines11020505. PMID: 36831041. (PubMed)
  • Lysak DH, Kock FVC, Mamone S, RSoong, Glöggler S, Simpson AJ
    In vivo singlet state filtered nuclear magnetic resonance: towards monitoring toxic responses inside living organisms.
    Chem. Sci. 2023 Jan 9;14(6):1413-1418. doi: 10.1039/d2sc06624f. eCollection 2023 Feb 8. PMID: 36794179. (PubMed)
  • Outeiro TF, El-Agnaf OM.
    The immune system in Parkinson's disease: From biology to diagnosis and therapeutic targets.
    Neurobiol Dis. 2023 Feb;177:105995. doi: 10.1016/j.nbd.2023.105995. PMID: 36627029. (PubMed)
  • Mougios N, Opazo F, Rizzoli SO, Reshetniak S.
    Trafficking proteins show limited differences in mobility across different postsynaptic spines.
    iScience. 2023 Jan 13;26(2):105971.doi: 10.1016/j.isci.2023.105971. eCollection 2023 Feb 17.. PMID: 36718370. (PubMed)
  • Cullinane PW, de Pablo Fernandez E, König A, Outeiro TF, Jaunmuktane Z, Warner TT.
    Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts.
    Mov Disord. 2023;38(2):162-177.doi: 10.1002/mds.29298. Epub 2022 Dec 26 . PMID: 6567671. (PubMed)
  • Hassanzadeh K, Morrone C, Akhtari K, Gerhardt E, Zaccagnini L, Outeiro TF, Feligioni M.
    Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.
    Mech Ageing Dev. 2023 Jan;209:111759. doi: 10.1016/j.mad.2022.111759. Epub 2022 Dec 2. PMID: 36464085. (PubMed)


  • Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF.
    Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity.
    J Parkinsons Dis. 2022;12(8):2397-2422.doi: 10.3233/JPD-223516. PMID: 36278361. (PubMed)
  • Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA.
    JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.
    Neurotox Res. 2022 Dec;40(6):2135-2147.doi: 10.1007/s12640-022-00559-7. Epub 2022 Aug 23. PMID: 35997936. (PubMed)
  • O'Sullivan ED, Mylonas KJ, Bell R, Carvalho C, Baird DP, Cairns C, Gallagher KM, Campbell R, Docherty M, Laird A, Henderson NC, Chandra T, Kirschner K, Conway B, Dihazi GH, Zeisberg M, Hughes J, Denby L, Dihazi H, Ferenbach DA.
    Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis .
    JCI Insight 2022 Nov 22;7(22):e154124.doi: 10.1172/jci.insight.154124. PMID: 36509292. (PubMed)
  • Lassen LB, Thomsen MS, Basso E, Füchtbauer EM, Füchtbauer A, Outeiro TF, Jensen PH, Moos T.
    Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.
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    Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo.
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    HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation.
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    Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity.
    Front Aging Neurosci. 2021 Mar 22;13:635760. doi: 10.3389/fnagi.2021.635760. (PubMed)
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    MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile.
    Front Cell Neurosci. 2021 Mar 17;15:641264. doi:10.3389/fncel.2021.641264. (PubMed)
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    Presynaptic activity and protein turnover are correlated at the single-synapse level.
    Cell Rep. 2021 Mar 16;34(11):108841.doi: 10.1016/j.celrep.2021.108841. (PubMed)
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    PAC-Mediated AKI Protection Is Critically Mediated but Does Not Exclusively Depend on Cell-Derived Microvesicles.
    Int. J. Nephrol. 2021 Mar 9;2021:8864183.doi: 10.1155/2021/8864183. eCollection 2021. (PubMed)
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    The vesicle cluster as a major organizer of synaptic composition in the short-term and long-term.
    Curr Opin Cell Biol. 2021 Mar 8;71:63-68. doi: 10.1016/ Online ahead of print. (PubMed)
  • Hintze A, Gültas M, Semmelhack EA, Wichmann C.
    Ultrastructural maturation of the endbulb of Held active zones comparing wild-type and otoferlin-deficient mice.
    i.Science. 2021 Mar 8;24(4):102282.doi: 10.1016/j.isci.2021.102282. eCollection 2021 Apr 23. (PubMed)
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    DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
    PLoS Genet. 2021 Mar 3;17(3):e1009407. doi: 10.1371/journal.pgen.1009407. (PubMed)
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    Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration.
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    Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
    Nat Neurosci. 2021 Mar;24(3):355-367. doi: 10.1038/s41593-020-00780-7. Epub 2021 Jan 25. (PubMed)
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    AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo.
    Cell Death Dis. 2021 Feb 26;12(2):213.doi: 10.1038/s41419-021-03503-3. (PubMed)
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    Discovery and Characterization of an ALFA-Tag-Specific Affinity Resin Optimized for Protein Purification at Low Temperatures in Physiological Buffer.
    Biomolecules. 2021 Feb 12;11(2):269. doi: 10.3390/biom11020269. (PubMed)
  • Brás IC, Outeiro TF.
    Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies.
    Cells. 2021 Feb 12;10(2):375. doi:10.3390/cells10020375. (PubMed)
  • Löhndorf A, Hosang L, Dohle W, Odoardi F, Waschkowski S-A, Rosche A, Bauche A, Winzer R, Tolosa E, Windhorst S, Marry S, Flügel A, Potter BVL, Diercks B-P, Guse AH.
    2-Methoxyestradiol and its derivatives inhibit store-operated Ca 2+ entry in T cells: Identification of a new and potent inhibitor.
    Biochim Biophys Acta Mol Cell Res. 2021 Feb 10;1868(6):118988.doi: 10.1016/j.bbamcr.2021.118988. Epub 2021 Feb 10. (PubMed)
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    Challenges facing quantitative large-scale optical super-resolution, and some simple solutions.
    iScience. 2021 Feb 3;24(3):102134. doi: 10.1016/j.isci.2021.102134. (PubMed)
  • Outeiro TF, Krisko A.
    Reply to: "Parkinson's Disease and COVID-19: Do We Need to Be More Patient?".
    Mov Disord. 2021 Feb;36(2):278-279.doi: 10.1002/mds.28482. (PubMed)
  • Filippou PS, Outeiro TF.
    Cancer and Parkinson's Disease: Common Targets, Emerging Hopes.
    Mov Disord. 2021 Feb;36(2):340-346. doi: 10.1002/mds.28425. Epub 2020 Dec 21. (PubMed)
  • Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO.
    NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover.
    BMC Mol Cell Biol. 2021 Jan 11;22(1):5. doi: 10.1186/s12860-020-00339-1. Epub 2020 Dec 21. (PubMed)
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    Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
    Nat Neurosci 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. (PubMed)
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    Simple multi-color super-resolution by X10 microscopy.
    Methods Cell Biol.2021;161:33-56. doi: 10.1016/bs.mcb.2020.04.016. Epub 2020 May 27. (PubMed)
  • Klionsky DJ, ...Lingor P, ... Outeiro TF, ... Tong CK.
    Guidelines for the use and interpretation of assays for monitoring autophagy.
    Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. (PubMed)
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    JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
    Neurotoxicology. 2021 Jan;82:89-98. doi: 10.1016/j.neuro.2020.11.005. Epub 2020 Nov 21. (PubMed)


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    Correction: Circumvention of common labelling artefacts using secondary nanobodies.
    Nanoscale. 2020 Dec 23;12(48):24543. doi: 10.1039/d0nr90279a. (PubMed)
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    A minimalist model to measure interactions between proteins and synaptic vesicles.
    Sci Rep. 2020 Dec 3;10(1):21086. doi: 10.1038/s41598-020-77887-1. (PubMed)
  • Dominguez-Meijide A, Vasili E, Outeiro TF.
    Pharmacological Modulators of Tau Aggregation and Spreading.
    Brain Sci. 2020 Nov 13;10(11):858.doi: 10.3390/brainsci10110858. (PubMed)
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    Signal-enhanced real-time magnetic resonance of enzymatic reactions at millitesla fields.
    Chem. Sci. 2020 Oct DOI: 10.1039/d0sc04884d. (pubs.rsc)
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    Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients.
    Aging (Albany NY). 2020 Oct 5;12(19):18889-18906. doi: 10.18632/aging.103935. Online ahead of print. (PubMed)
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    Quantitative Synaptic Biology: A Perspective on Techniques, Numbers and Expectations.
    Int J Mol Sci. 2020 Oct 2;21(19):7298. doi: 10.3390/ijms21197298 (PubMed)
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    SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime.
    Aging (Albany NY). 2020 Sep 29;12(18):18778-18789.doi: 10.18632/aging.103989. Online ahead of print. (PubMed)
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    Axon guidance receptors: Endocytosis, trafficking and downstream signaling from endosomes.
    Prog Neurobiol. 2020 Sep 28:101916. doi: 10.1016/j.pneurobio.2020.101916. Epub ahead of print. (PubMed)
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    Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.
    J. Clin.Med. 2020 Sep 22;9(9):3051.doi: 10.3390/jcm9093051.PMID: 32971813 (PubMed)
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    Localized singlet-filtered MRS in vivo.
    NMR Biomed. 2020 Sep 1;e4400. doi: 10.1002/nbm.4400. Online ahead of print. (PubMed)
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    Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases.
    Antioxidants (Basel). 2020 Aug 26;9(9):789.doi: 10.3390/antiox9090789. (PubMed)
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    The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders.
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    RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies.
    Brain Pathol. 2020 Aug 6.doi: 10.1111/bpa.12890. Online ahead of print. (PubMed)
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    Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease.
    Neuron. 2020 Aug 5;107(3):417-435.doi: 10.1016/j.neuron.2020.06.005. Epub 2020 Jun 23. (PubMed)
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    Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
    Sci Rep. 2020 Jul 30;10(1):12827.doi: 10.1038/s41598-020-69744-y. (PubMed)
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    Novel Secondary Ion Mass Spectrometry Methods for the Examination of Metabolic Effects at the Cellular and Subcellular Levels.
    Front Behav Neurosci.2020 Jul 20;14:124.doi: 10.3389/fnbeh.2020.00124. eCollection 2020. (PubMed)
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    The Secretome Analysis of Activated Human Renal Fibroblasts Revealed Beneficial Effect of the Modulation of the Secreted Peptidyl-Prolyl Cis-Trans Isomerase A in Kidney Fibrosis.
    Cells. 2020 Jul 18;9(7):1724.doi: 10.3390/cells9071724. PMID:32708451;PMC7407823 (PubMed)
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    Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins.
    Angew Chem Int Ed Engl 2020 Sep 28;59(40):17732-17738. doi: 10.1002/anie.202003825. Epub 2020 Jul 13. (PubMed)
  • Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM.
    The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.
    Front Pharmacol. 2020 Jul 9;11:985.doi: 10.3389/fphar.2020.00985. eCollection 2020. (PubMed)
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    Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.
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    A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
    EMBO J. 2020 Aug 17;39(16):e104596.doi: 10.15252/embj.2020104596. (PubMed)
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    Human cerebrospinal fluid data for use as spectral library, for biomarker research
    Data Brief. 2020 Jul 19;32:106048.doi: 10.1016/j.dib.2020.106048. eCollection 2020 Oct. (PubMed)
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    Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases
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    Elemental quantification and analysis of structural abnormalities in neurons from Parkinson's-diseased brains by X-ray fluorescence microscopy and diffraction.
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    Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
    Nat Commun. 2020 Jun 25;11(1):3208. doi: 10.1038/s41467-020-17003-z.  (PubMed)
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    A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol
    Nat Commun. 2020 Jun 1;11(1):2729.doi: 10.1038/s41467-020-16575-0. (PubMed)
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    Increased alpha-synuclein tear fluid levels in patients with Parkinson’s disease.
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    Protein trapping leads to altered synaptic proteostasis in synucleinopathies.
    Review, FEBS J. 2020 May 13.doi: 10.1111/febs.15364. Online ahead of print. (PubMed)
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    X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy.
    Dalton Trans. 2020 May 11.doi: 10.1039/d0dt01138j. Online ahead of print. (PubMed)
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    Synucleinopathies: Where we are and where we need to go.
    Review Neurochem. 2020 May;153(4):433-454.doi: 10.1111/jnc.14965. Epub 2020 Feb 19. (PubMed)
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    Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein.
    FASEB J. 2020 May;34(5):6718-6728.doi: 10.1096/fj.201902936R. Epub 2020 Apr 7. (PubMed)
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    Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in Vivo, enhances translation, and modulates splicing.
    Cell Death Differ. 2020 Apr 27. doi: 10.1038/s41418-020-0543-y. Online ahead of print. (PubMed)
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    SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration.
    Mov Disord. 2020 May;35(5):716-720.doi: 10.1002/mds.28084. Epub 2020 Apr 24. (PubMed)
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    The Interplay Between Proteostasis Systems and Parkinson's Disease.
    Review, Adv Exp Med Biol. 2020;1233:223-236.doi: 10.1007/978-3-030-38266-7_9. (PubMed)
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    Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity.
    Sci Rep. 2020 Apr 8;10(1):6064.doi: 10.1038/s41598-020-62678-5. (PubMed)
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    A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
    Pharmacol Rep. 2020 Apr;72(2):456-464.doi: 10.1007/s43440-019-00032-x. Epub 2020 Jan 15. (PubMed)
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    Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.
    Cell Rep. 2020 Mar 17;30(11):3632-3643.e8. doi: 10.1016/j.celrep.2020.02.083. (PubMed)
  • Brás IC, Xylaki M, Outeiro TF.
    Mechanisms of alpha-synuclein toxicity: An update and outlook.
    Prog Brain Res. 2020;252:91-129.doi: 10.1016/bs.pbr.2019.10.005. Epub 2019 Nov 23. (PubMed)
  • Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ.
    Are genetic and idiopathic forms of Parkinson’s disease the same disease?
    J Neurochem. 2020 Mar;152(5):515-522. doi: 10.1111/jnc.14902. Epub 2019 Dec 8. Review. (PubMed)
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    Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients.
    J Clin Med. 2020 Feb 27;9(3). pii: E639. doi: 10.3390/jcm9030639. (PubMed)
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    Singlet-filtered NMR spectroscopy
    Science Advances 21 Feb 2020: Vol. 6, no. 8, eaaz1955. DOI: 10.1126/sciadv.aaz1955
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    The courage to change science.
    EMBO Rep. 2020 Mar 4;21(3):e50124.doi: 10.15252/embr.202050124. Epub 2020 Feb 20. (PubMed)
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    AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson’s Disease.
    Mol Neurobiol. 2020 Feb;57(2):685-697. doi: 10.1007/s12035-019-01744-0. Epub 2019 Aug 24. (PubMed)
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    Elemental fingerprint: Reassessment of a cerebrospinal fluid biomarker for Parkinson’s disease.
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    Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model.
    Pharmacol Biochem Behav. 2020 Feb;189:172828. doi: 10.1016/j.pbb.2019.172828. Epub 2019 Nov 28. (PubMed)
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    AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
    J Cell Sci. 2020 Jan 22;133(2). pii: jcs236737. doi: 10.1242/jcs.236737. (PubMed)
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    Synucleinopathies: Where we are and where we need to go.
    J Neurochem. 2020 Jan 20. doi: 10.1111/jnc.14965. [Epub ahead of print] (PubMed)
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    A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
    Pharmacol Rep. 2020 Jan 15. doi: 10.1007/s43440-019-00032-x. [Epub ahead of print] (PubMed)
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    Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.
    Neuroscience. 2020 Jan 1;424:58-71. doi: 10.1016/j.neuroscience.2019.08.046. Epub 2019 Nov 1. (PubMed)
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    Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.
    Biochim Biophys Acta Proteins Proteom. 2020 Jan;1868(1):140298. doi: 10.1016/j.bbapap.2019.140298. Epub 2019 Oct 30. (PubMed)
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    Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases.
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    Mapping Cellular Microenvironments: Proximity Labeling and Complexome Profiling (Seventh Symposium of the Göttingen Proteomics Forum).
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    The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications.
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    Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
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Maidorn M, Rizzoli SO, Opazo F.
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