Year of the publications
2024
- Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M.
The maintenance of oocytes in the mammalian ovary involves extreme protein longevity.
Nat Cell Biol. 2024 Jun 20. doi: 10.1038/s41556-024-01442-7. Online ahead of print. PMID: 38902423. (PubMed)
- Curto Y, Carceller H, Klimczak P, Perez-Rando M, Wang Q, Grewe K, Kawaguchi R, Rizzoli SO, Geschwind D, Nave KA, Teruel-Marti V, Singh M, Ehrenreich H, Nácher J.
Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus.
Mol Psychiatry. 2024 Apr 15. doi: 10.1038/s41380-024-02528-2. Online ahead of print. PMID: 38622200. (PubMed)
- Erdmann L, Santos PI, Rieper P, Klafki HW, Beutner D, Wiltfang J, Outeiro TF, Setz C.
Automated Capillary Electrophoresis Immunoblot for the Detection of Alpha-Synuclein in Mouse Tissue.
J Parkinsons Dis. 2024 Apr 5. doi: 10.3233/JPD-230379. Online ahead of print. PMID: 38578903. (PubMed)
- Outeiro TF, Kalia LV, Bezard E, Ferrario J, Lin CH, Salama M, Standaert DG, Taiwo L, Takahashi R, Vila M, Mollenhauer B, Svenningsson P; MDS Basic Science Special Interest Group Steering Committee.
Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice
Mov Disord. 2024 Apr 4. doi: 10.1002/mds.29802. Online ahead of print. PMID: 38576081. (PubMed)
- Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A Jr, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J, Moser T.
Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.
Protein Cell. 2024 2024 Apr 1;15(4):305-312. doi: 10.1093/procel/pwad058. PMID: 38066594. (PubMed)
- Unterauer EM, Boushehri SS, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, Opazo F, Fornasiero EF, Jungmann R.
Spatial proteomics in neurons at single-protein resolution.
Cell 2024 Mar 28;187(7):1785-1800.e16. doi: 10.1016/j.cell.2024.02.045 PMID: 38552614. (PubMed)
- Bosbach C, Gatzemeier LM, Bloch von Blottnitz KI, König A, Diederichsen U, Steinem C, Outeiro TF.
Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments.
Org Biomol Chem. 2024 Mar 27;22(13):2670-2676. doi: 10.1039/d4ob00225c. PMID: 38483440. (PubMed)
- Plácido E, Koss DJ, Outeiro TF, Brocardo PS.
Altered hippocampal doublecortin expression in Parkinson's disease.
J Neurochem. 2024 Mar 14. doi: 10.1111/jnc.16101. Online ahead of print. PMID: 38485468. (PubMed)
- Chopra A, Lang AE, Höglinger G, Outeiro TF.
Towards a biological diagnosis of PD.
Review Parkinsonism Relat Disord. 2024 Mar 6:106078.doi: 10.1016/j.parkreldis.2024.106078. Online ahead of print. PMID: 38472075. (PubMed)
- Rubilar JC, Outeiro TF, Klein AD.
The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson's therapeutics.
Brain 2024 Mar 4:awae070. doi: 10.1093/brain/awae070. Online ahead of print. PMID: 38437875. (PubMed)
- da Silva ANR, Pereira GRC, Bonet LFS, Outeiro TF, De Mesquita JF.
In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease.
J Cell Biochem. 2024 Mar;125(3):e30523. doi: 10.1002/jcb.30523. Epub 2024 Jan 18. PMID: 38239037. (PubMed)
- Alsouri S, Ambrose A, Mougios N, Paglilla N, Mayr F, Choi K, Loeber J, Chapuy B, Haeupl B, Opazo F, Oellerich T, Gold M, Engelke M.
Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors.
Immunol. 2024 Mar;54(3):e2350774. doi: 10.1002/eji.202350774. Epub 2024 Feb 1 PMID: 38299456. (PubMed)
- Tatenhorst L, Maass F, Paul F, Dambeck V, Bähr M, Dono R, Lingor P.
Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.
Sci Rep. 2024 Feb 29;14(1):5005. doi: 10.1038/s41598-024-54800-8. PMID: 38424123. (PubMed)
- Galka D, Ali TT, Bast A, Niederleithinger M, Gerhardt E, Motosugi R, Sakata E, Knop M, Outeiro TF, Popova B, Braus GH.
Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1.
Aging Cell. 2024 Feb 28:e14128. doi: 10.1111/acel.14128. Online ahead of print. PMID: 38415292. (PubMed)
- Malik N, Miah MU, Galgani A, McAleese K, Walker L, LeBeau FE, Attems J, Outeiro TF, Thomas A, Koss DJ.
Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change.
Acta Neuropathol. 2024 Feb 14;147(1):40. doi: 10.1007/s00401-024-02691-4. PMID: 38353753. (PubMed)
- Höglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE.
A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria.
Lancet Neurol. 2024 Feb;23(2):191-204. doi: 10.1016/S1474-4422(23)00404-0. PMID: 38267191. (PubMed)
- Quesnel A, Martin LD, Tarzi C, Lenis VP, Coles N, Islam M, Angione C, Outeiro TF, Khundakar AA, Filippou PS.
Uncovering potential diagnostic and pathophysiological roles of α-synuclein and DJ-1 in melanoma.
Cancer Med. 2024 Jan 8;13(1):e6900. doi: 10.1002/cam4.6900. Online ahead of print. PMID: 38189631. (PubMed)
- Aubrey LD, Ninkina N, Ulamec SM, Abramycheva NY, Vasili E, Devine OM, Wilkinson M, Mackinnon E, Limorenko G, Walko M, Muwanga S, Amadio L, Peters OM, Illarioshkin SN, Outeiro TF, Ranson NA, Brockwell DJ, Buchman VL, Radford SE.
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309700120. doi: 10.1073/pnas.2309700120. Epub 2024 Jan 3. PMID: 38170745. (PubMed)
- Chopra A, Outeiro TF.
Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies.
Brain. 2024 Jan 4;147(1):81-90. doi: 10.1093/brain/awad260. PMID: 37526295. (PubMed)
- DʼEste E, Lukinavičius G, Lincoln R, Opazo F, Fornasiero EF.
Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations.
Trends Cell Biol. 2024 Jan 5:S0962-8924(23)00239-8.doi: 10.1016/j.tcb.2023.12.001. Online ahead of print. PMID: 38184400. (PubMed)
2023
- de Jong-Bolm D, Sadeghi M, Bogaciu CA, Bao G, Klaehn G, Hoff M, Mittelmeier L, Basmanav FB, Opazo F, Noé F, Rizzoli SO.
Protein nanobarcodes enable single-step multiplexed fluorescence imaging.
PLOS Biol. 2023 Dec 11;21(12):e3002427.doi: 10.1371/journal.pbio.3002427. eCollection 2023 Dec. PMID: 38079451. (PubMed)
- Hintze A, Lange F, Steyer AM, Anstatt J, Möbius W, Jakobs S, Wichmann C.
Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus.
iScience. 2023 Dec 8;27(1):108700. doi: 10.1016/j.isci.2023.108700. eCollection 2024 Jan 19. PMID: 38213623. (PubMed)
- Monteiro Neto JR, Ribeiro GD, Magalhães RSS, Follmer C, Outeiro TF, Eleutherio ECA.
Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis.
Biochim Biophys Acta Mol Basis Dis. 2023 Dec;1869(8):166835. doi: 10.1016/j.bbadis.2023.166835. Epub 2023 Aug 7. PMID: 37558009. (PubMed)
- Alexander LT et al.
Protein target highlights in CASP15: Analysis of models by structure providers.
Proteins. 2023 Dec;91(12):1571-1599.doi: 10.1002/prot.26545. Epub 2023 Jul 26. PMID: 37493353. (PubMed)
- Vieira TCRG, Barros CA, Domingues R, Outeiro TF.
PrP meets alpha-synuclein: Molecular mechanisms and implications for disease.
J Neurochem. 2023 Oct 19. doi: 10.1111/jnc.15992. Online ahead of print. PMID: 37855859. (PubMed)
- Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO.
High-resolution analysis of bound Ca2+ in neurons and synapses.
Life Sci Alliance. 2023 Oct 13;7(1):e202302030. doi: 10.26508/lsa.202302030. Print 2024 Jan. PMID: 37833073. (PubMed)
- Klein AD, Outeiro TF.
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria.
Nat Commun. 2023 Oct 11;14(1):6383. doi: 10.1038/s41467-023-42107-7. PMID: 37821433. (PubMed)
- Real KQZV, Mougios N, Rehm R, Sograte-Idrissi S , Albert L , Rahimi AM, Maidorn M, Hentze J , Martínez-Carranza M , Hosseini H, Saal KA, Oleksiievets N, Prigge M, Tsukanov R, Stenmark P, Fornasiero EF, Opazo F.
A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy.
Small Methods. 2023 Oct;7(10):e2300218.doi: 10.1002/smtd.202300218. Epub 2023 Jul 8. PMID: 37421204. (PubMed)
- Michanski S, Kapoor R*, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra KF, Neef J, Strenzke N, Moser T, Wichmann C.
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
EMBO Rep. 2023 Sep 6;24(9):e56702. doi: 10.15252/embr.202256702. Epub 2023 Jul 21. PMID: 37477166. (PubMed)
- Hune TLK, Mamone S, Schmidt AB, Mahú I, D’Apolito N, Wiedermann D, Brüning J, Glöggler S.
Hyperpolarized Multi-organ Spectroscopy of Liver and Brain Using 1-13C-Pyruvate Enhjanced via Parahydrogen.
Appl. Magn. Reson. doi: 10.1007/s00723-023-01578-z (2023). (ResearchSquare)
- de Maissin H, Groß PR, Mohiuddin O, Weigt M, Nagel L, Herzog M, Wang Z, Willing R, Reichardt W, Pichotka M, Heß L, Reinheckel T, Jessen HJ, Zeiser R, Bock M, von Elverfeldt D, Zaitsev M, Korchak S, Glöggler S, Hövener JB, Chekmenev EY, Schilling F, Knecht S, Schmidt AB.
In Vivo Metabolic Imaging of [1-13 C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen.
Angew. Chem. Int. Ed. Engl. 2023 Sep 4;62(36):e202306654. doi: 10.1002/anie.202306654. Epub 2023 Jul 25. . PMID: 37439488. (PubMed)
- Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP.
Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
J Neurochem. 2023 Sep 3. doi: 10.1111/jnc.15956. Online ahead of print. PMID: 37661637. (PubMed)
- Flores-Leon M, Outeiro TF.
More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy.
Acta Neuropathol. 2023 Sep;146(3):369-385. doi: 10.1007/s00401-023-02601-0. Epub 2023 Jul 8. PMID: 37236414. (PubMed)
- Georgiev SV, Rizzoli SO.
The long-loop recycling (LLR) of synaptic components as a question of economics.
Mol Cell Neurosci. 2023 Sep:126:103862. doi: 10.1016/j.mcn.2023.103862 PMID: 37236414. (PubMed)
- Xylaki M, Chopra A, Weber S, Bartl M, Outeiro TF, Mollenhauer B.
Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis.
Mov Disord. 2023 Sep;38(9):1585-1597. doi: 10.1002/mds.29497. Epub 2023 Jul 14. PMID: 37449706. (PubMed)
- Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M,Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P.
Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.
J Neurochem. 2023 Sep;166(5):862-874. doi: 10.1111/jnc.15924. Epub 2023 Jul 28. PMID: 37515330. (PubMed)
- Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A.
Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson's Disease.
Int J Mol Sci. 2023 Aug 30;24(17):13435. doi: 10.3390/ijms241713435. PMID: 37686236. (PubMed)
- Sant'Anna R, Robbs BK, de Freitas JA, Dos Santos PP, König A, Outeiro TF, Foguel D.
The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.
Mol Med. 2023 Aug 18;29(1):111. doi: 10.1186/s10020-023-00704-8. PMID: 37596531. (PubMed)
- Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi-Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C.
Age-dependent structural reorganization of utricular ribbon synapses.
Front Cell Dev Biol. 2023 Aug 10:11:1178992.doi: 10.3389/fcell.2023.1178992. eCollection 2023. PMID: 37635868. (PubMed)
- Plácido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS.
Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington's Disease Effects in YAC128 Mice.
Int J Mol Sci. 2023 Aug 9;24(16):12607. doi: 10.3390/ijms241612607. PMID: 37628801. (PubMed)
- Outeiro TF, Vieira TCRG.
AI and protein structure and function in neurological disease: relevance to disease management.
Nat Rev Neurol. 2023 Aug;19(8):453-454. doi: 10.1038/s41582-023-00840-z. PMID: 37394622. (PubMed)
- Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP.
Targeting Biomolecular Condensation and Protein Aggregation against Cancer.
Chem Rev. 2023 Jul 26;123(14):9094-9138. doi: 10.1021/acs.chemrev.3c00131. Epub 2023 Jun 28. PMID: 37379327. (PubMed)
- Zhang S, Dauer K, Strohäker T, Tatenhorst L, Caldi Gomes L, Mayer S , Jung BC , Kim WS, Lee SJ, Becker S, Liesche-Starnecker F, Zweckstetter M, Lingor P.
Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.
Brain Pathol. 2023 Jul 24. doi: 10.1111/bpa.13196. Online ahead of print. PMID: 37485772. (PubMed)
- Peifer M, Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F.
Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.
Mol Biol Cell. 2023 Jul 1;34(8):ar81. doi: 10.1091/mbc.E23-03-0077. Epub 2023 May 10. PMID: 37163320. (PubMed)
- Gasparotto J, Somensi N, Girardi CS, Bittencourt RR, de Oliveira LM, Hoefel LP, Scheibel IM, Peixoto DO, Moreira JCF, Outeiro TF, Gelain DP.
Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease.
J Neurochem. 2023 Jun 28.doi: 10.1111/jnc.15890. Online ahead of print. PMID: 37381043. (PubMed)
- Ding Y, Stevanato G, von Bonin F, Kube D, Glöggler S.
Real-time cell metabolism assessed repeatedly on the same cells via para-hydrogen induced polarization.
Chem. Sci. 2023 Jun 20;14(28):7642-7647. doi: 10.1039/d3sc01350b. eCollection 2023 Jul 19. PMID: 37476713. (PubMed)
- Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF.
Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation.
Chemistry. 2023 Jun 13;29(33):e202300649.doi: 10.1002/chem.202300649. Epub 2023 Apr 27. PMID: 36971510. (PubMed)
- Gelain DP, Bittencourt RR, Bastos Mendes LF, Moreira JCF, Outeiro TF.
RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.
J Parkinsons Dis. 2023; May 31.doi: 10.3233/JPD-230070. Online ahead of print. PMID: 37270812. (PubMed)
- Domingos J, Teixeira Bastos MDC, Couto R, Cameira AR, Cardoso AL, Reffóios A, Magalhães S, Massano J, Outeiro TF.
People with Early Onset Parkinson's Disease: Empowered to Improve Care.
J Parkinsons Dis. 2023 13(4):633-636.doi: 10.3233/JPD-230039. PMID: 37182901. (PubMed)
- Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ.
Defining the Riddle in Order to Solve It: There Is More Than One "Parkinson's Disease" .
Mov Disord. 2023 May 8.doi: 10.1002/mds.29419. Online ahead of print. PMID: 37156737. (PubMed)
- Hosang L, Löhndorf A, Dohle W, Rosche A, Marry S, Diercks B-P, Müller-Kirschbaum LC, Flügel LT, Potter BVL, Odoardi F, Guse AH, Flügel A.
2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.
Biochim Biophys Acta Mol Cell Res. 2023 Aug;1870(6):119485. doi: 10.1016/j.bbamcr.2023.119485. Epub 2023 May 6. . PMID: 37150482. (PubMed)
- Kilisch M, Gere-Becker M, Wüstefeld L, Bonnas C, Crauel A , Mechmershausen M, Martens H, Götzke H, Opazo F, Frey S.
Simple and Highly Efficient Detection of PSD95 Using a Nanobody and Its Recombinant Heavy-Chain Antibody Derivatives.
Int J Mol Sci. 2023 Apr 14;24(8):7294.doi: 10.3390/ijms24087294. PMID: 37108454. (PubMed)
- Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN.
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Nat Commun. 2023 Apr 6;14(1):1918. doi: 10.1038/s41467-023-37561-2. PMID: 37024503. (PubMed)
- Hülskötter K, Lühder F, Leitzen E, Flügel A, Baumgärtner W.
CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis.
Front Immunol. 2023 Apr 5;14:1105432. doi: 10.3389/fimmu.2023.1105432. eCollection 2023. PMID: 37090733. (PubMed)
- Saal KA, Shaib AH, Mougios N , Crzan D, Opazo F, Rizzoli SO.
Heat denaturation enables multicolor X10-STED microscopy.
Sci Rep. 2023 Apr 1;13(1):5366. doi: 10.1038/s41598-023-32524-5. PMID: 37005431. (PubMed)
- Stevanato G, Ding Y, Mamone S, Jagtap A, Korchak S, Glöggler S.
Real-Time Pyruvate Chemical Conversion Monitoring Enabled by PHIP.
J. Am. Chem. Soc. 2023 Mar 15;145(10):5864-5871. doi: 10.1021/jacs.2c13198. Epub 2023 Mar 1 . PMID: 36857108. (PubMed)
- Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V.
Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation.
Cells. 2023 Mar 6;12(5):818. doi: 10.3390/cells12050818. PMID: 36899953. (PubMed)
- Quesnel A, Coles N, Angione C, Dey P, Polvikoski TM, Outeiro TF, Islam M, Khundakar AA, Filippou PS.
Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy.
BMC Cancer. 2023 Feb 21;23(1):174.doi: 10.1186/s12885-023-10588-w. PMID: 36809974. (PubMed)
- Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF.
miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.
J Parkinsons Dis. 2023; 13(2):179-196. doi: 10.3233/JPD-225055. PMID: 36744345. (PubMed)
- Shvachiy L, Geraldes V, Outeiro TF.
Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease.
Antioxid Redox Signal. 2023 Mar 6. doi: 10.1089/ars.2022.0076. Online ahead of print. PMID: 36641635. (PubMed)
- Marsili L, Sharma J, Outeiro TF, Colosimo C.
Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials.
Biomedicines. 2023 Feb 9;11(2):505. doi: 10.3390/biomedicines11020505. PMID: 36831041. (PubMed)
- Lysak DH, Kock FVC, Mamone S, RSoong, Glöggler S, Simpson AJ
In vivo singlet state filtered nuclear magnetic resonance: towards monitoring toxic responses inside living organisms.
Chem. Sci. 2023 Jan 9;14(6):1413-1418. doi: 10.1039/d2sc06624f. eCollection 2023 Feb 8. PMID: 36794179. (PubMed)
- Outeiro TF, El-Agnaf OM.
The immune system in Parkinson's disease: From biology to diagnosis and therapeutic targets.
Neurobiol Dis. 2023 Feb;177:105995. doi: 10.1016/j.nbd.2023.105995. PMID: 36627029. (PubMed)
- Mougios N, Opazo F, Rizzoli SO, Reshetniak S.
Trafficking proteins show limited differences in mobility across different postsynaptic spines.
iScience. 2023 Jan 13;26(2):105971.doi: 10.1016/j.isci.2023.105971. eCollection 2023 Feb 17.. PMID: 36718370. (PubMed)
- Cullinane PW, de Pablo Fernandez E, König A, Outeiro TF, Jaunmuktane Z, Warner TT.
Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts.
Mov Disord. 2023;38(2):162-177.doi: 10.1002/mds.29298. Epub 2022 Dec 26 . PMID: 6567671. (PubMed)
- Hassanzadeh K, Morrone C, Akhtari K, Gerhardt E, Zaccagnini L, Outeiro TF, Feligioni M.
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.
Mech Ageing Dev. 2023 Jan;209:111759. doi: 10.1016/j.mad.2022.111759. Epub 2022 Dec 2. PMID: 36464085. (PubMed)
2022
- Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF.
Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity.
J Parkinsons Dis. 2022;12(8):2397-2422.doi: 10.3233/JPD-223516. PMID: 36278361. (PubMed)
- Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA.
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.
Neurotox Res. 2022 Dec;40(6):2135-2147.doi: 10.1007/s12640-022-00559-7. Epub 2022 Aug 23. PMID: 35997936. (PubMed)
- O'Sullivan ED, Mylonas KJ, Bell R, Carvalho C, Baird DP, Cairns C, Gallagher KM, Campbell R, Docherty M, Laird A, Henderson NC, Chandra T, Kirschner K, Conway B, Dihazi GH, Zeisberg M, Hughes J, Denby L, Dihazi H, Ferenbach DA.
Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis .
JCI Insight 2022 Nov 22;7(22):e154124.doi: 10.1172/jci.insight.154124. PMID: 36509292. (PubMed)
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The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.
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Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.
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Biomolecules. 2022 Feb 18;12(2):324.doi: 10.3390/biom12020324. PMID: 35204823. (PubMed)
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Mol Neurobiol. 2022 Feb;59(2):1273-1284.doi: 10.1007/s12035-021-02713-2. Epub 2022 Jan 4. PMID: 34984585. (PubMed)
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Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Brain. 2022 Jan 6;awac002.doi: 10.1093/brain/awac002. Online ahead of print. PMID: 34999780. (PubMed)
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Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R.
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JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats.
Neurotoxicology. 2021 Dec;87:70-85. doi: 10.1016/j.neuro.2021.08.017. Epub 2021 Sep 2. (PubMed) - Nyamsuren G, Rapp G, Dihazi H, Zeisberg EM, Tampe D, Tampe B, Zeisberg M.
PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation.
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Double-edged effects of tamoxifen-in-oil-gavage on an infectious murine model for multiple sclerosis.
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Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences.
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Proteome analysis of an aggressive and a hypoaggressive isolates of Fusarium oxysporum f. sp albedinis showing several differently expressed-proteins related to the aggressiveness.
Physiol Mol. Plant Pathol.2021 in press. doi.org/10.1016/j.pmpp.2021.101738 (Sciencedirect) - Berghoff SA, Spieth L, Sun T, Hosang L, Depp C, Sasmita AO, Vasileva MH, Scholz P, Zhao Y, Krueger-Burg D, Wichert S, Brown ER, Michail K, Nave K-A, Bonn S, Odoardi F, Rossner M, Ischebeck T, Edgar JM, Saher G.
Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice.
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Tubular microdomains of Rab7-positive endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth disease 2B.
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Molecular Profiles of Amyloid-β Proteoforms in Typical and Rapidly Progressive Alzheimer's Disease.
Mol Neurobiol.2021 Oct 7.doi: 10.1007/s12035-021-02566-9. Online ahead of print. (PubMed) - Flores-León M, Lázaro DF, Shvachiy L, Krisko A, Outeiro TF.
In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies.
Biochim Biophys Acta Proteins Proteom. 2021 Oct;1869(10):140693. doi: 10.1016/j.bbapap.2021.140693. Epub 2021 Jul 5. (PubMed) - Butola T, Alvanos T, Hintze A , Koppensteiner P, Kleindienst D, Shigemoto R, Wichmann C, Moser T.
RIM-Binding Protein 2 Organizes Ca 2+ Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse.
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A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines.
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Held Up in Traffic-Defects in the Trafficking Machinery in Charcot-Marie-Tooth Disease.
Front Mol Neurosci. 2021 Aug 16;14:695294. doi: 10.3389/fnmol.2021.695294. eCollection 2021. PMID: 34483837 Free PMC article. Review. (PubMed) - Hülskötter K, Lühder F, Flügel A, Herder V, Baumgärtner W.
Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection.
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Erratum to: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Brain. 2021 Jul 28;144(6):e58.doi: 10.1093/brain/awab175.PMID: 34100910 (PubMed) - Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF.
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.
NPJ Parkinsons Dis. 2021 Jul 26;7(1):65. doi: 10.1038/s41531-021-00203-9. (PubMed) - Glowacki SK, Gomes de Castro MA, Yip KM, Asadpour O, Münchhalfen M, Engels N, Opazo F.
A fluorescent probe for STED microscopy to study NIP-specific B cells.
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Gold-Conjugated Nanobodies for Targeted Imaging Using High-Resolution Secondary Ion Mass Spectrometry.
Nanomaterials. 2021 Jul 10;11(7):1797.doi: 10.3390/nano11071797. (PubMed) - Joppe KDN, Tatenhorst L, Caldi Gomes L, Zhang S, Parvaz M, Carboni E, Roser AE, El DeBakey H, Bähr M, Vogel-Mikuš K, Ip CW, Becker S, Zweckstetter M, Lingor P.
Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils.
J Neurochem.2021 Jun 27.doi: 10.1111/jnc.15461. Online ahead of print. (PubMed) - Martinez Hernandez A, Silbern I, Geffers I, Tatenhorst L, Becker S, Urlaub H, Zweckstetter M, Griesinger C, Eichele G.
Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein.
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Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity.
Sci Adv. 2021 Jun 9;7(24):eabf2806. doi: 10.1126/sciadv.abf2806. Print 2021 Jun. (PubMed) - Vahsen BF, Lingor P.
ULK1 as a novel therapeutic target in neurodegeneration.
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Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development.
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Correlative fluorescence microscopy, transmission electron microscopy and secondary ion mass spectrometry (CLEM-SIMS) for cellular imaging
PLoS One. 2021 May 10;16(5):e0240768.doi: 10.1371/journal.pone.0240768. eCollection 2021. (PubMed) - Agüi-Gonzalez P, Guobin B, Gomes de Castro MA, Rizzoli SO, Phan NTN.
Secondary Ion Mass Spectrometry Imaging Reveals Changes in the Lipid Structure of the Plasma Membranes of Hippocampal Neurons following Drugs Affecting Neuronal Activity.
ACS Chem Neurosci. 2021 May 5;12(9):1542-1551. doi: 10.1021/acschemneuro.1c00031. Epub 2021 Apr 26. (PubMed) - Koss DJ, Campesan S, Giorgini F, Outeiro TF.
Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.
Mov Disord. 2021 May 3. doi:10.1002/mds.28605. Epub ahead of print. (PubMed) - Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P.
Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
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Alpha-synuclein oligomerization and aggregation: A model will always be a model: This is a response to "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". Read the reply on "Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model". The articles are accompanied by a Preface "How good are cellular models?".
J Neurochem. 2021 May;157(4):889-890.doi: 10.1111/jnc.15264. Epub 2021 Feb 13. (PubMed) - Outeiro TF.
Alpha-Synuclein Antibody Characterization: Why Semantics Matters.
Neurobiol. 2021 May;58(5):2202-2203. doi: 10.1007/s12035-020-02269-7. Epub 2021 Jan 7. (PubMed) - Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M.
Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo.
Mol Ther. 2021 Apr 30:S1525-0016(21)00249-5. doi: 10.1016/j.ymthe.2021.04.035. Epub ahead of print. (PubMed) - Outeiro TF, Heutink P, Bezard E, Cenci AM.
From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease.
Mov Disord. 2021 Apr;36(4):832-841. doi: 10.1002/mds.28387. Epub 2020 Nov 16. (PubMed) - Popova B, Wang D, Rajavel A, Dhamotharan K, Lázaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH.
Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation.
Front Mol Neurosci. 2021 Apr 12;14:659926. doi: 10.3389/fnmol.2021.659926. (PubMed) - Erskine D, Koss D, Korolchuk VI, Outeiro TF.
Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders.
Acta Neuropathol. 2021 Apr;141(4):511-526. doi: 10.1007/s00401-021-02266-7. Epub 2021 Jan 30. (PubMed) - Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF.
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo.
Neurobiol Dis. 2021 Apr;151:105256. doi: 10.1016/j.nbd.2021.105256. Epub 2021 Jan 8. (PubMed) - Outeiro TF.
Emerging concepts in synucleinopathies.
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HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation.
Sci Signal. 2021 Mar 23;14(675):eabd5647. doi: 10.1126/scisignal.abd5647. PMID: 33758062. (PubMed) - Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB.
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity.
Front Aging Neurosci. 2021 Mar 22;13:635760. doi: 10.3389/fnagi.2021.635760. (PubMed) - Jacinto S, Guerreiro P, de Oliveira RM, Cunha-Oliveira T, Santos MJ, Grazina M, Rego AC, Outeiro TF.
MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile.
Front Cell Neurosci. 2021 Mar 17;15:641264. doi:10.3389/fncel.2021.641264. (PubMed) - Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V.
Presynaptic activity and protein turnover are correlated at the single-synapse level.
Cell Rep. 2021 Mar 16;34(11):108841.doi: 10.1016/j.celrep.2021.108841. (PubMed) - Dihazi H, Schwarze K , Patschan S, Müller GA, Ritter O, Zeisberg M, Patschan D.
PAC-Mediated AKI Protection Is Critically Mediated but Does Not Exclusively Depend on Cell-Derived Microvesicles.
Int. J. Nephrol. 2021 Mar 9;2021:8864183.doi: 10.1155/2021/8864183. eCollection 2021. (PubMed) - Reshetniak S, Rizzoli SO.
The vesicle cluster as a major organizer of synaptic composition in the short-term and long-term.
Curr Opin Cell Biol. 2021 Mar 8;71:63-68. doi: 10.1016/j.ceb.2021.02.007. Online ahead of print. (PubMed) - Hintze A, Gültas M, Semmelhack EA, Wichmann C.
Ultrastructural maturation of the endbulb of Held active zones comparing wild-type and otoferlin-deficient mice.
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DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
PLoS Genet. 2021 Mar 3;17(3):e1009407. doi: 10.1371/journal.pgen.1009407. (PubMed) - Winkler A, Wrzos C, Haberl M, Weil MT, Gao M, Möbius W, Odoardi F, Thal DR, Chang M, Opdenakker G, Bennett JL, Nessler S, Stadelmann C.
Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration.
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Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Nat Neurosci. 2021 Mar;24(3):355-367. doi: 10.1038/s41593-020-00780-7. Epub 2021 Jan 25. (PubMed) - Ribas VT, Vahsen BF, Tatenhorst L, Estrada V, Dambeck V, Alves Almeida R, Bähr M, Michel U, Koch JC, Müller HW, Lingor P.
AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo.
Cell Death Dis. 2021 Feb 26;12(2):213.doi: 10.1038/s41419-021-03503-3. (PubMed) - Kilisch M, Götzke H, Gere-Becker M, Crauel A, Opazo F, Frey S.
Discovery and Characterization of an ALFA-Tag-Specific Affinity Resin Optimized for Protein Purification at Low Temperatures in Physiological Buffer.
Biomolecules. 2021 Feb 12;11(2):269. doi: 10.3390/biom11020269. (PubMed) - Brás IC, Outeiro TF.
Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies.
Cells. 2021 Feb 12;10(2):375. doi:10.3390/cells10020375. (PubMed) - Löhndorf A, Hosang L, Dohle W, Odoardi F, Waschkowski S-A, Rosche A, Bauche A, Winzer R, Tolosa E, Windhorst S, Marry S, Flügel A, Potter BVL, Diercks B-P, Guse AH.
2-Methoxyestradiol and its derivatives inhibit store-operated Ca 2+ entry in T cells: Identification of a new and potent inhibitor.
Biochim Biophys Acta Mol Cell Res. 2021 Feb 10;1868(6):118988.doi: 10.1016/j.bbamcr.2021.118988. Epub 2021 Feb 10. (PubMed) - Dankovich TM, Rizzoli SO.
Challenges facing quantitative large-scale optical super-resolution, and some simple solutions.
iScience. 2021 Feb 3;24(3):102134. doi: 10.1016/j.isci.2021.102134. (PubMed) - Outeiro TF, Krisko A.
Reply to: "Parkinson's Disease and COVID-19: Do We Need to Be More Patient?".
Mov Disord. 2021 Feb;36(2):278-279.doi: 10.1002/mds.28482. (PubMed) - Filippou PS, Outeiro TF.
Cancer and Parkinson's Disease: Common Targets, Emerging Hopes.
Mov Disord. 2021 Feb;36(2):340-346. doi: 10.1002/mds.28425. Epub 2020 Dec 21. (PubMed) - Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO.
NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover.
BMC Mol Cell Biol. 2021 Jan 11;22(1):5. doi: 10.1186/s12860-020-00339-1. Epub 2020 Dec 21. (PubMed) - Berghoff SA, Spieth L, Sun T,Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G.
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
Nat Neurosci 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. (PubMed) - Truckenbrodt S, Rizzoli SO.
Simple multi-color super-resolution by X10 microscopy.
Methods Cell Biol.2021;161:33-56. doi: 10.1016/bs.mcb.2020.04.016. Epub 2020 May 27. (PubMed) - Klionsky DJ, ...Lingor P, ... Outeiro TF, ... Tong CK.
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. (PubMed) - Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y.
JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
Neurotoxicology. 2021 Jan;82:89-98. doi: 10.1016/j.neuro.2020.11.005. Epub 2020 Nov 21. (PubMed)
2020
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Correction: Circumvention of common labelling artefacts using secondary nanobodies.
Nanoscale. 2020 Dec 23;12(48):24543. doi: 10.1039/d0nr90279a. (PubMed) - Perego E, Reshetniak S, Lorenz C, Hoffmann C, Milovanović D, Rizzoli SO, Köster S.
A minimalist model to measure interactions between proteins and synaptic vesicles.
Sci Rep. 2020 Dec 3;10(1):21086. doi: 10.1038/s41598-020-77887-1. (PubMed) - Dominguez-Meijide A, Vasili E, Outeiro TF.
Pharmacological Modulators of Tau Aggregation and Spreading.
Brain Sci. 2020 Nov 13;10(11):858.doi: 10.3390/brainsci10110858. (PubMed) - Korchak S, Jagtap A, Glöggler S.
Signal-enhanced real-time magnetic resonance of enzymatic reactions at millitesla fields.
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Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients.
Aging (Albany NY). 2020 Oct 5;12(19):18889-18906. doi: 10.18632/aging.103935. Online ahead of print. (PubMed) - Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff C.
Quantitative Synaptic Biology: A Perspective on Techniques, Numbers and Expectations.
Int J Mol Sci. 2020 Oct 2;21(19):7298. doi: 10.3390/ijms21197298 (PubMed) - Domingues R, Lippi A, Setz C, Outeiro TF, Krisko A.
SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime.
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Axon guidance receptors: Endocytosis, trafficking and downstream signaling from endosomes.
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Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.
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Localized singlet-filtered MRS in vivo.
NMR Biomed. 2020 Sep 1;e4400. doi: 10.1002/nbm.4400. Online ahead of print. (PubMed) - Menezes R, Foito A, Jardim C, Costa I, Garcia G, Rosado-Ramos R, Freitag S, Alexander CJ, Outeiro TF, Stewart D, Santos CN.
Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases.
Antioxidants (Basel). 2020 Aug 26;9(9):789.doi: 10.3390/antiox9090789. (PubMed) - Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF , Schüle B.
The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders.
Review, Int J Mol Sci. 2020 Aug 10;21(16):5724.doi: 10.3390/ijms21165724. (PubMed) - Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF.
RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies.
Brain Pathol. 2020 Aug 6.doi: 10.1111/bpa.12890. Online ahead of print. (PubMed) - Harris SS, Wolf F, De Strooper B, Busche MA.
Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease.
Neuron. 2020 Aug 5;107(3):417-435.doi: 10.1016/j.neuron.2020.06.005. Epub 2020 Jun 23. (PubMed) - Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF.
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Sci Rep. 2020 Jul 30;10(1):12827.doi: 10.1038/s41598-020-69744-y. (PubMed) - Bonnin EA, Rizzoli SO.
Novel Secondary Ion Mass Spectrometry Methods for the Examination of Metabolic Effects at the Cellular and Subcellular Levels.
Front Behav Neurosci.2020 Jul 20;14:124.doi: 10.3389/fnbeh.2020.00124. eCollection 2020. (PubMed) - Dihazi GH, Eltoweissy M, Jahn O, Tampe B, Zeisberg M, Wülfrath HS, Müller GA, Dihazi H.
The Secretome Analysis of Activated Human Renal Fibroblasts Revealed Beneficial Effect of the Modulation of the Secreted Peptidyl-Prolyl Cis-Trans Isomerase A in Kidney Fibrosis.
Cells. 2020 Jul 18;9(7):1724.doi: 10.3390/cells9071724. PMID:32708451;PMC7407823 (PubMed) - Mann FA, Herrmann N, Opazo F, Kruss S.
Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins.
Angew Chem Int Ed Engl 2020 Sep 28;59(40):17732-17738. doi: 10.1002/anie.202003825. Epub 2020 Jul 13. (PubMed) - Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM.
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.
Front Pharmacol. 2020 Jul 9;11:985.doi: 10.3389/fphar.2020.00985. eCollection 2020. (PubMed) - Sato M, Mizuta K, Islam T, Kawano M, Sekine Y, Takekawa T, Gomez-Dominguez D, Schmidt A, Wolf F, Kim K, Yamakawa H, Ohkura M, Lee MG, Fukai T, Nakai J, Hayashi Y.
Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.
Cell Rep. 2020 Jul 7;32(1):107864.doi: 10.1016/j.celrep.2020.107864. (PubMed) - Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO.
A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
EMBO J. 2020 Aug 17;39(16):e104596.doi: 10.15252/embj.2020104596. (PubMed) - Schilde LM, Steinbach S, Serschnitzki B, Maass F, Bähr M, Lingor P, Marcus K, May C.
Human cerebrospinal fluid data for use as spectral library, for biomarker research
Data Brief. 2020 Jul 19;32:106048.doi: 10.1016/j.dib.2020.106048. eCollection 2020 Oct. (PubMed) - Outeiro TF, Krisko A.
Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases
Mov Disord. 2020 Jul;35(7):1106-1107.doi: 10.1002/mds.28178. (PubMed) - Joppe K, Nicolas JD, Grünewald TA, Eckermann M, Salditt T, Lingor P.
Elemental quantification and analysis of structural abnormalities in neurons from Parkinson's-diseased brains by X-ray fluorescence microscopy and diffraction.
Biomed Opt Express. 2020 Jun 2;11(7):3423-3443. doi: 10.1364/BOE.389408. eCollection 2020 Jul 1. (PubMed) - JeJean P, Anttonen T, Michanski S, de Diego AMG, Steyer AM, Neef A, Oestreicher D, Kroll J, Nardis N, Pangršič T, Möbius W, Ashmore J, Wichmann C, Moser T.
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
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A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol
Nat Commun. 2020 Jun 1;11(1):2729.doi: 10.1038/s41467-020-16575-0. (PubMed) - Maass F, Rikker S, Dambeck V, Warth C, Tatenhorst L, Csoti I, Schmitz M, Zerr I, Leha A, Bähr M, Lingor P.
Increased alpha-synuclein tear fluid levels in patients with Parkinson’s disease.
Sci Rep.2020 May 22;10(1):8507.doi: 10.1038/s41598-020-65503-1. (PubMed) - Santos PI, Outeiro TF.
Protein trapping leads to altered synaptic proteostasis in synucleinopathies.
Review, FEBS J. 2020 May 13.doi: 10.1111/febs.15364. Online ahead of print. (PubMed) - Cukierman DS, Lázaro DF, Sacco P, Ferreira PR, Diniz R, Fernández CO, Outeiro TF, Rey NA.
X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy.
Dalton Trans. 2020 May 11.doi: 10.1039/d0dt01138j. Online ahead of print. (PubMed) - Brás IC, Dominguez-Meijide A, Gerhardt E, Koss D, Lázaro DF, Santos PI, Vasili E, Xylaki M, Outeiro TF.
Synucleinopathies: Where we are and where we need to go.
Review Neurochem. 2020 May;153(4):433-454.doi: 10.1111/jnc.14965. Epub 2020 Feb 19. (PubMed) - Vicente Miranda H, Chegão A, Oliveira MS, Fernandes Gomes B, Enguita FJ, Outeiro TF.
Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein.
FASEB J. 2020 May;34(5):6718-6728.doi: 10.1096/fj.201902936R. Epub 2020 Apr 7. (PubMed) - Vahsen BF, Ribas VT, Sundermeyer J, Boecker A, Dambeck V, Lenz C, Shomroni O, Caldi Gomes L, Tatenhorst L, Barski E, Roser AE, Michel U, Urlaub H, Salinas G, Bähr M, Koch JC, Lingor P.
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in Vivo, enhances translation, and modulates splicing.
Cell Death Differ. 2020 Apr 27. doi: 10.1038/s41418-020-0543-y. Online ahead of print. (PubMed) - Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A.
SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration.
Mov Disord. 2020 May;35(5):716-720.doi: 10.1002/mds.28084. Epub 2020 Apr 24. (PubMed) - Lázaro DF, Outeiro TF.
The Interplay Between Proteostasis Systems and Parkinson's Disease.
Review, Adv Exp Med Biol. 2020;1233:223-236.doi: 10.1007/978-3-030-38266-7_9. (PubMed) - Francelle L, Outeiro TF, Rappold GA.
Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity.
Sci Rep. 2020 Apr 8;10(1):6064.doi: 10.1038/s41598-020-62678-5. (PubMed) - Vale N , Alves C, Sharma V, Lázaro DF, Silva S, Gomes P, Outeiro TF.
A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
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Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.
Cell Rep. 2020 Mar 17;30(11):3632-3643.e8. doi: 10.1016/j.celrep.2020.02.083. (PubMed) - Brás IC, Xylaki M, Outeiro TF.
Mechanisms of alpha-synuclein toxicity: An update and outlook.
Prog Brain Res. 2020;252:91-129.doi: 10.1016/bs.pbr.2019.10.005. Epub 2019 Nov 23. (PubMed) - Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ.
Are genetic and idiopathic forms of Parkinson’s disease the same disease?
J Neurochem. 2020 Mar;152(5):515-522. doi: 10.1111/jnc.14902. Epub 2019 Dec 8. Review. (PubMed) - Koziolek M, Mueller GA, Dihazi GH, Jung K, Altubar C, Wallbach M, Markovic I, Raddatz D, Jahn O, Karaköse H, Lenz C, Urlaub H, Dihazi A, El Meziane A, Dihazi H.
Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients.
J Clin Med. 2020 Feb 27;9(3). pii: E639. doi: 10.3390/jcm9030639. (PubMed) - Mamone S, Rezaei-Ghaleh N, Opazo F, Griesinger C, Glöggler S.
Singlet-filtered NMR spectroscopy
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The courage to change science.
EMBO Rep. 2020 Mar 4;21(3):e50124.doi: 10.15252/embr.202050124. Epub 2020 Feb 20. (PubMed) - Balke D, Tatenhorst L, Dambeck V, Ribas VT, Vahsen BF, Michel U, Bähr M, Lingor P.
AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson’s Disease.
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Elemental fingerprint: Reassessment of a cerebrospinal fluid biomarker for Parkinson’s disease.
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Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model.
Pharmacol Biochem Behav. 2020 Feb;189:172828. doi: 10.1016/j.pbb.2019.172828. Epub 2019 Nov 28. (PubMed) - Kroll J, Özçete ÖD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T.
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
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Synucleinopathies: Where we are and where we need to go.
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A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
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Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.
Neuroscience. 2020 Jan 1;424:58-71. doi: 10.1016/j.neuroscience.2019.08.046. Epub 2019 Nov 1. (PubMed) - Masaracchia C, König A, Valiente-Gabioud AA, Peralta P, Favretto F, Strohäker T, Lázaro DF, Zweckstetter M, Fernandez CO, Outeiro TF.
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.
Biochim Biophys Acta Proteins Proteom. 2020 Jan;1868(1):140298. doi: 10.1016/j.bbapap.2019.140298. Epub 2019 Oct 30. (PubMed) - Lázaro DF, Bellucci A, Brundin P, Outeiro TF.
Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases.
Editorial, Front Mol Neurosci. 2020 Jan 17;12:312.doi: 10.3389/fnmol.2019.00312. eCollection 2019. (PubMed) - Maass F, Michalke B, Willkommen D, Schulte C, Tönges L, Boerger M, Zerr I, Bähr M, Lingor P.
Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson’s disease.
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The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.
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Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1.
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The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism.
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Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
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De Novo Designed α-Helical Coiled-Coil Peptides as Scaffolds for Chemical Reactions.
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Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Switch for Spin Singlet States.
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Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Spin Singlet State Switch.
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Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding
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Yeast-Based Screens to Target Alpha-Synuclein Toxicity.
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Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast.
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Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration.
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Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
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The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
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Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.
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Decoration of Coiled-Coil Peptides with N-Cysteine Peptide Thioesters As Cyclic Peptide Precursors Using Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) Click Reaction.
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Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
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Parahydrogen-Based Hyperpolarization for Biomedicine.
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X10 expansion microscopy enables 25-nm resolution on conventional microscopes.
EMBO Rep. 2018 Jul 9. pii: e45836. doi: 10.15252/embr.201845836. (PubMed) - Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO.
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
EMBO J. 2018 Aug 1;37(15). pii: e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27. (PubMed) - Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V,Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.
Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print] (PubMed) - McCormick J, Korchak S, Mamone S, Ertas YN, Liu Z, Verlinsky L, Wagner S, Glöggler S, Bouchard LS.
More Than 12% Polarization and 20 Minutes Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water.
Angew. Chem. Int. Ed. 2018, 57, 10692-10696. (PubMed) - Roser AE, Caldi Gomes L, Halder R, Jain G, Maass F, Tönges L, Tatenhorst L, Bähr M, Fischer A, Lingor P.
miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.
Mol Ther Nucleic Acids. 2018 Jun 1;11:9-22. doi: 10.1016/j.omtn.2018.01.005. Epub 2018 Feb 2. (PubMed) - Vaz RL, Outeiro TF, Ferreira JJ.
Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review.
Front Neurol. 2018 Jun 1;9:347. doi: 10.3389/fneur.2018.00347. eCollection 2018. (PubMed) - Korchak S, Yang S, Mamone S, Glöggler S.
Pulsed Magnetic Resonance to Signal-Enhance Metabolites within Seconds by utilizing para-Hydrogen.
ChemistryOpen. 2018 May 8;7(5):344-348. doi: 10.1002/open.201800024. eCollection 2018 May. (PubMed) - Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE,Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN.
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.
Sci Rep. 2018 May 3;8(1):6965. doi: 10.1038/s41598-018-25118-z. (PubMed) - Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.
The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
Mol Neurobiol. 2018 Apr 19. doi:10.1007/s12035-018-1084-y. (PubMed) - Groth MC, Rink WM, Meyer NF, Thomas F.
Kinetic Studies on Strand Displacement in de novo Designed Parallel Heterodimeric Coiled Coils.
Chem. Sci. 2018, 9, 4308–4316. (PubMed) - Biosa A, Outeiro TF, Bubacco L, Bisaglia M.
Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View.
Mol Neurobiol. 2018 Mar 28. doi: 10.1007/s12035-018-1025-9. [Epub ahead of print] Review. (PubMed) - Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO.
Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.
Biophys J. 2018 Mar 13;114(5):1036-1045. doi: 10.1016/j.bpj.2018.01.003. (PubMed) - Fourcade S, Outeiro TF, Pujol A.
SIRT2 in age-related neurodegenerative disorders.
Aging (Albany NY). 2018 Mar 3;10(3):295-296. doi:10.18632/aging/101397. (PubMed) - König A, Vicente Miranda H, Outeiro TF.
Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease.
J Parkinsons Dis. 2018;8(1):33-43. doi: 10.3233/JPD-171285. (PubMed) - Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, Wichmann C, Strenzke N, Grabner C, Moser T.
The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
Elife. 2018 Jan 12;7. pii: e29275. doi: 10.7554/eLife.29275. (PubMed) - Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C,Meyer T.
Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study.
World J Biol Psychiatry. 2018 Jan 11:1-9. doi: 10.1080/15622975.2017.1417636. [Epub ahead of print] (PubMed) - Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.
Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16. (PubMed) - Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.
Guidelines and recommendations on yeast cell death nomenclature.
Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review. (PubMed)
2017
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Correction: Gene Expression Differences in Peripheral Blood of Parkinson’s Disease Patients with Distinct Progression Profiles.
PLoS One. 2017 Dec 28;12(12):e0190552. doi: 10.1371/journal.pone.0190552. eCollection 2017 (PubMed) - Bozek T, Blazekovic A, Perkovic MN, Jercic KG, Sustar A, Smircic-Duvnjak L, Outeiro TF, Pivac N, Borovecki F.
The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus.
Diabetol Metab Syndr. 2017 Dec 4;9:97. doi: 10.1186/s13098-017-0295-0. eCollection 2017. (PubMed) - Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al’Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA,Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.
Building Bridges through Science.
Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028. (PubMed) - Krinner S, Butola T, Jung S, Wichmann C, Moser T.
RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.
Front Cell Neurosci. 2017 Nov 2;11:334. doi: 10.3389/fncel.2017.00334. eCollection 2017. (PubMed) - Lemos V, de Oliveira RM, Naia L, Szegö É, Ramos E, Pinho S, Magro F, Cavadas C, Rego AC, Costa V, Outeiro TF, Gomes P.
The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Hum Mol Genet. 2017 Nov 1;26(21):4105-4117. doi: 10.1093/hmg/ddx298. (PubMed) - Guedes LC, Chan RB, Gomes MA, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Carriço JA, Alcalay RN, Ferreira JJ, Outeiro TF, Miltenberger-Miltenyi G.
Serum lipid alterations in GBA-associated Parkinson’s disease.
Parkinsonism Relat Disord. 2017 Nov;44:58-65. doi: 10.1016/j.parkreldis.2017.08.026. Epub 2017 Sep 1. (PubMed) - López-León M, Outeiro TF, Goya RG.
Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain.
Ageing Res Rev. 2017 Nov;40:168-181. doi: 10.1016/j.arr.2017.09.002. Epub 2017 Sep 10. Review. (PubMed) - Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.
α-synuclein interacts with PrP(C) to induce cognitive impairment through mGluR5 and NMDAR2B.
Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25. (PubMed) - Butola T, Wichmann C, Moser T.
Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.
Front Synaptic Neurosci. 2017 Oct 25;9:14. doi: 10.3389/fnsyn.2017.00014. eCollection 2017. (PubMed) - Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF.
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease.
Sci Rep. 2017 Oct 20;7(1):13713. doi: 10.1038/s41598-017-14175-5. (PubMed) - Roodveldt C, Outeiro TF, Braun JEA.
Editorial: Molecular Chaperones and Neurodegeneration.
Front Neurosci. 2017 Oct 11;11:565. doi: 10.3389/fnins.2017.00565. eCollection 2017. (PubMed) - Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.
Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.
Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260. (PubMed) - Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA.
Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.
Mol Neurobiol. 2018 Jun;55(6):5269-5281. doi: 10.1007/s12035-017-0755-4. Epub 2017 Sep 7. (PubMed) - Correia Guedes L, Reimão S, Paulino P, Nunes RG, Bouça-Machado R, Abreu D, Gonçalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, Campos J, Outeiro TF, Sampaio C, Bonifati V, Ferreira JJ.
Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson’s disease.
Mov Disord. 2017 Sep;32(9):1331-1333. doi: 10.1002/mds.27083. Epub 2017 Jul 7. (PubMed) - Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego ÉM, Kerimoglu C, Gerhardt E, Rego AC, Fischer A, Bonn S, Outeiro TF.
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.
Hum Mol Genet. 2017 Jun 15;26(12):2231-2246. doi: 10.1093/hmg/ddx114. (PubMed) - Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056. (PubMed) - de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. (PubMed) - Gomes de Castro MA, Höbartner C, Opazo F.
Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy.
PLoS One. 2017 Feb 24;12(2):e0173050. doi: 10.1371/journal.pone.0173050. eCollection 2017. (PubMed)
2016
Maidorn M, Rizzoli SO, Opazo F.
Tools and limitations to study the molecular composition of synapses by fluorescence microscopy.
Biochem J. 2016 Oct 15;473(20):3385-3399. Review. (PubMed)
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