Publications

Since the BIN’s inception in 2016, its scientists have published the results of their research in numerous scientific journals.

Year of the publications

2023

  • Bonnin EA, Golmohammadi A, Rehm R, Tetzlaff C, Rizzoli SO.
    High-resolution analysis of bound Ca2+ in neurons and synapses.
    Life Sci Alliance. 2023 Oct 13;7(1):e202302030. doi: 10.26508/lsa.202302030. Print 2024 Jan. PMID: 37833073. (PubMed)
  • Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P.
    Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease.
    J Neurochem. 2023 Sep;166(5):862-874. doi: 10.1111/jnc.15924. Epub 2023 Jul 28. PMID: 37515330. (PubMed)
  • Georgiev SV, Rizzoli SO.
    The long-loop recycling (LLR) of synaptic components as a question of economics.
    Mol Cell Neurosci. 2023 Sep:126:103862. doi: 10.1016/j.mcn.2023.103862 PMID: 37236414. (PubMed)
  • Hune TLK, Mamone S, Schmidt AB, Mahú I, D’Apolito N, Wiedermann D, Brüning J, Glöggler S.
    Hyperpolarized Multi-organ Spectroscopy of Liver and Brain Using 1-13C-Pyruvate Enhjanced via Parahydrogen.
    Appl. Magn. Reson. doi: 10.1007/s00723-023-01578-z (2023). (ResearchSquare)
  • de Maissin H, Groß PR, Mohiuddin O, Weigt M, Nagel L, Herzog M, Wang Z, Willing R, Reichardt W, Pichotka M, Heß L, Reinheckel T, Jessen HJ, Zeiser R, Bock M, von Elverfeldt D, Zaitsev M, Korchak S, Glöggler S, Hövener JB, Chekmenev EY, Schilling F, Knecht S, Schmidt AB.
    In Vivo Metabolic Imaging of [1-13 C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen.
    Angew. Chem. Int. Ed. Engl. 2023 Sep 4;62(36):e202306654. doi: 10.1002/anie.202306654. Epub 2023 Jul 25. . PMID: 37439488. (PubMed)
  • Zhang S, Dauer K, Strohäker T, Tatenhorst L, Caldi Gomes L, Mayer S , Jung BC , Kim WS, Lee SJ, Becker S, Liesche-Starnecker F, Zweckstetter M, Lingor P.
    Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.
    Brain Pathol. 2023 Jul 24. doi: 10.1111/bpa.13196. Online ahead of print. PMID: 37485772. (PubMed)
  • Peifer M, Schmidt A, Finegan T, Häring M, Kong D, Fletcher AG, Alam Z, Grosshans J, Wolf F.
    Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.
    Mol Biol Cell. 2023 Jul 1;34(8):ar81. doi: 10.1091/mbc.E23-03-0077. Epub 2023 May 10. PMID: 37163320. (PubMed)
  • Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi-Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C.
    Age-dependent structural reorganization of utricular ribbon synapses.
    Front Cell Dev Biol. 2023 Aug 10:11:1178992.doi: 10.3389/fcell.2023.1178992. eCollection 2023. PMID: 37635868. (PubMed)
  • Michanski S, Kapoor R*, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra KF, Neef J, Strenzke N, Moser T, Wichmann C.
    Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
    EMBO Rep. 2023 Sep 6;24(9):e56702. doi: 10.15252/embr.202256702. Epub 2023 Jul 21. PMID: 37477166. (PubMed)
  • Ding Y, Stevanato G, von Bonin F, Kube D, Glöggler S.
    Real-time cell metabolism assessed repeatedly on the same cells via para-hydrogen induced polarization.
    Chem. Sci. 2023 Jun 20;14(28):7642-7647. doi: 10.1039/d3sc01350b. eCollection 2023 Jul 19. PMID: 37476713. (PubMed)
  • Gatzemeier LM, Meyer F, Diederichsen U, Outeiro TF.
    Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation.
    Chemistry. 2023 Jun 13;29(33):e202300649.doi: 10.1002/chem.202300649. Epub 2023 Apr 27. PMID: 36971510. (PubMed)
  • Gelain DP, Bittencourt RR, Bastos Mendes LF, Moreira JCF, Outeiro TF.
    RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.
    J Parkinsons Dis. 2023; May 31.doi: 10.3233/JPD-230070. Online ahead of print. PMID: 37270812. (PubMed)
  • Domingos J, Teixeira Bastos MDC, Couto R, Cameira AR, Cardoso AL, Reffóios A, Magalhães S, Massano J, Outeiro TF.
    People with Early Onset Parkinson's Disease: Empowered to Improve Care.
    J Parkinsons Dis. 2023 13(4):633-636.doi: 10.3233/JPD-230039. PMID: 37182901. (PubMed)
  • Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ.
    Defining the Riddle in Order to Solve It: There Is More Than One "Parkinson's Disease" .
    Mov Disord. 2023 May 8.doi: 10.1002/mds.29419. Online ahead of print. PMID: 37156737. (PubMed)
  • Hosang L, Löhndorf A, Dohle W, Rosche A, Marry S, Diercks B-P, Müller-Kirschbaum LC, Flügel LT, Potter BVL, Odoardi F, Guse AH, Flügel A.
    2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.
    Biochim Biophys Acta Mol Cell Res. 2023 Aug;1870(6):119485. doi: 10.1016/j.bbamcr.2023.119485. Epub 2023 May 6. . PMID: 37150482. (PubMed)
  • Kilisch M, Gere-Becker M, Wüstefeld L, Bonnas C, Crauel A , Mechmershausen M, Martens H, Götzke H, Opazo F, Frey S.
    Simple and Highly Efficient Detection of PSD95 Using a Nanobody and Its Recombinant Heavy-Chain Antibody Derivatives.
    Int J Mol Sci. 2023 Apr 14;24(8):7294.doi: 10.3390/ijms24087294. PMID: 37108454. (PubMed)
  • Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN.
    Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
    Nat Commun. 2023 Apr 6;14(1):1918. doi: 10.1038/s41467-023-37561-2. PMID: 37024503. (PubMed)
  • Hülskötter K, Lühder F, Leitzen E, Flügel A, Baumgärtner W.
    CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis.
    Front Immunol. 2023 Apr 5;14:1105432. doi: 10.3389/fimmu.2023.1105432. eCollection 2023. PMID: 37090733. (PubMed)
  • Saal KA, Shaib AH, Mougios N , Crzan D, Opazo F, Rizzoli SO.
    Heat denaturation enables multicolor X10-STED microscopy.
    Sci Rep. 2023 Apr 1;13(1):5366. doi: 10.1038/s41598-023-32524-5. PMID: 37005431. (PubMed)
  • Stevanato G, Ding Y, Mamone S, Jagtap A, Korchak S, Glöggler S.
    Real-Time Pyruvate Chemical Conversion Monitoring Enabled by PHIP.
    J. Am. Chem. Soc. 2023 Mar 15;145(10):5864-5871. doi: 10.1021/jacs.2c13198. Epub 2023 Mar 1 . PMID: 36857108. (PubMed)
  • Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V.
    Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation.
    Cells. 2023 Mar 6;12(5):818. doi: 10.3390/cells12050818. PMID: 36899953. (PubMed)
  • Quesnel A, Coles N, Angione C, Dey P, Polvikoski TM, Outeiro TF, Islam M, Khundakar AA, Filippou PS.
    Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy.
    BMC Cancer. 2023 Feb 21;23(1):174.doi: 10.1186/s12885-023-10588-w. PMID: 36809974. (PubMed)
  • Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF.
    miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.
    J Parkinsons Dis. 2023; 13(2):179-196. doi: 10.3233/JPD-225055. PMID: 36744345. (PubMed)
  • Shvachiy L, Geraldes V, Outeiro TF.
    Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease.
    Antioxid Redox Signal. 2023 Mar 6. doi: 10.1089/ars.2022.0076. Online ahead of print. PMID: 36641635. (PubMed)
  • Marsili L, Sharma J, Outeiro TF, Colosimo C.
    Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials.
    Biomedicines. 2023 Feb 9;11(2):505. doi: 10.3390/biomedicines11020505. PMID: 36831041. (PubMed)
  • Lysak DH, Kock FVC, Mamone S, RSoong, Glöggler S, Simpson AJ
    In vivo singlet state filtered nuclear magnetic resonance: towards monitoring toxic responses inside living organisms.
    Chem. Sci. 2023 Jan 9;14(6):1413-1418. doi: 10.1039/d2sc06624f. eCollection 2023 Feb 8. PMID: 36794179. (PubMed)
  • Outeiro TF, El-Agnaf OM.
    The immune system in Parkinson's disease: From biology to diagnosis and therapeutic targets.
    Neurobiol Dis. 2023 Feb;177:105995. doi: 10.1016/j.nbd.2023.105995. PMID: 36627029. (PubMed)
  • Mougios N, Opazo F , Rizzoli SO, Reshetniak S.
    Trafficking proteins show limited differences in mobility across different postsynaptic spines.
    iScience. 2023 Jan 13;26(2):105971.doi: 10.1016/j.isci.2023.105971. eCollection 2023 Feb 17.. PMID: 36718370. (PubMed)
  • Cullinane PW, de Pablo Fernandez E, König A, Outeiro TF, Jaunmuktane Z, Warner TT.
    Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts.
    Mov Disord. 2023;38(2):162-177.doi: 10.1002/mds.29298. Epub 2022 Dec 26 . PMID: 6567671. (PubMed)
  • Hassanzadeh K, Morrone C, Akhtari K, Gerhardt E, Zaccagnini L, Outeiro TF, Feligioni M.
    Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.
    Mech Ageing Dev. 2023 Jan;209:111759. doi: 10.1016/j.mad.2022.111759. Epub 2022 Dec 2. PMID: 36464085. (PubMed)

2022

  • Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF.
    Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity.
    J Parkinsons Dis. 2022;12(8):2397-2422.doi: 10.3233/JPD-223516. PMID: 36278361. (PubMed)
  • Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA.
    JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.
    Neurotox Res. 2022 Dec;40(6):2135-2147.doi: 10.1007/s12640-022-00559-7. Epub 2022 Aug 23. PMID: 35997936. (PubMed)
  • O'Sullivan ED, Mylonas KJ, Bell R, Carvalho C, Baird DP, Cairns C, Gallagher KM, Campbell R, Docherty M, Laird A, Henderson NC, Chandra T, Kirschner K, Conway B, Dihazi GH, Zeisberg M, Hughes J, Denby L, Dihazi H, Ferenbach DA.
    Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis .
    JCI Insight 2022 Nov 22;7(22):e154124.doi: 10.1172/jci.insight.154124. PMID: 36509292. (PubMed)
  • Lassen LB, Thomsen MS, Basso E, Füchtbauer EM, Füchtbauer A, Outeiro TF, Jensen PH, Moos T.
    Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.
    Cells. 2022 Nov 18;11(22):3673.doi: 10.3390/cells11223673. PMID: 36429099. (PubMed)
  • Brás IC, Khani MH, Riedel D, Parfentev I, Gerhardt E, van Riesen C, Urlaub H, Gollisch T, Outeiro TF.
    Ectosomes and exosomes modulate neuronal spontaneous activity.
    J Proteomics. 2022 Oct 30;269:104721.doi: 10.1016/j.jprot.2022.104721. Epub 2022 Sep 8.. PMID: 36089191. (PubMed)
  • Chakrabarti R, Jaime Tobon LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C.
    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses.
    eLife doi.org/10.1101/2022.05.10.491334 (BioRxiv)
  • Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F.
    Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane .
    Biomedicines. 2022 Sep 15;10(9):2294.doi: 10.3390/biomedicines10092294. PMID: 36140394. (PubMed)
  • Shvachiy L, Amaro-Leal Â, Outeiro TF, Rocha I, Geraldes V.
    From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms.
    Biology (Basel). 2022 Aug 3;11(8):1164.doi: 10.3390/biology11081164. PMID: 36009791. (PubMed)
  • Queiroz DD, Ribeiro TP, Gonçalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD.
    A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity.
    Biochim Biophys Acta Mol Basis Dis. 2022 Oct. 1;1868(10):166475.doi: 10.1016/j.bbadis.2022.166475. Epub 2022 Jun 28. PMID: 35777688. (PubMed)
  • Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I.
    IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.
    Proc Natl Acad Sci U S A 2022 Aug 16;119(33):e2121040119. doi: 10.1073/pnas.2121040119. Epub 2022 Aug 9. PMID: 35943986. (PubMed)
  • Magalhães RSS, Boechat FC, Brasil AA, Neto JRM, Ribeiro GD, Paranhos LH, Neves de Souza N, Vieira T, Outeiro TF, Neves BC, Eleutherio ECA.
    Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1.
    J Cell Biochem. 2022 Aug 9; doi: 10.1002/jcb.30317. Online ahead of print. PMID: 35944097. (PubMed)
  • Burk K.
    The endocytosis, trafficking, sorting and signaling of neurotrophic receptors.
    Book chapter. Prog.Mol.Biol. Transl. Science 2022 Jul 30; doi.org/10.1016/bs.pmbts.2022.06.033. (ScienceDirect)
  • Koss DJ, Erskine D, Porter A, Palmoski P, Menon H, Todd OGJ, Leite M, Attems J, Outeiro TF.
    Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies.
    Acta Neuropathol Commun. 2022 Jul 6;10(1):98.doi: 10.1186/s40478-022-01403-x. PMID: 35794636. (PubMed)
  • abatas Glowacki S, Agüi-Gonzalez P, Sograte-Idrissi S, Jähne S, Opazo F, Phan NTN, Rizzoli SO.
    An iodine-containing probe as a tool for molecular detection in secondary ion mass spectrometry.
    Chem Commun (Camb.) 2022 Jul 5;58(54):7558-7561.doi: 10.1039/d2cc02290g. PMID: 35708485. (PubMed)
  • Merlini A, Haberl M, Strauß J, Hildebrand L, Genc N, Franz J, Chilov D, Alitalo K, Flügel-Koch C, Stadelmann C, Flügel A, Odoardi F.
    Distinct roles of the meningeal layers in CNS autoimmunity.
    Nat Neurosci. 2022 Jul;25(7):887-899. doi: 10.1038/s41593-022-01108-3. Epub 2022 Jun 30. PMID: 35773544. (PubMed)
  • Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PDC, Copello FDR, Lizarraga L, Rossetti G, Carloni P, Zweckstetter M, Outeiro TF, Eimer S, Griesinger C, Fernández CO.
    Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations.
    Protein Sci. 2022 Jul;31(7):e4360.doi: 10.1002/pro.4360. PMID: 35762717. (PubMed)
  • Domingues R, Sant'Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TF.
    Extracellular alpha-synuclein: Sensors, receptors, and responses.
    Neurobiol Dis. 2022 Jun 15;168:105696. doi: 10.1016/j.nbd.2022.105696. Epub 2022 Mar 20. PMID: 35321855 Review. (PubMed)
  • Jordan KL, Koss DJ, Outeiro TF, Giorgini F.
    Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease.
    Biomedicines. 2022 May 16;10(5):1141.doi: 10.3390/biomedicines10051141. PMID: 35625878. (PubMed)
  • Schaffner SL, Wassouf Z, Lazaro DF, Xylaki M, Gladish N, Lin DTS, MacIsaac J, Ramadori K, Hentrich T, Schulze-Hentrich JM, Outeiro TF, Kobor MS.
    Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.
    Hum Mol Genet. 2022 May 14;ddac104.doi: 10.1093/hmg/ddac104. Online ahead of print. PMID: 35567546. (PubMed)
  • Chegão A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H.
    Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes.
    NPJ Parkinsons Dis. 2022 Apr 25;8(1):51. doi: 10.1038/s41531-022-00314-x. . PMID: 35468899. (PubMed)
  • Li F, Fornasiero EF, Dankovich TM, Kluever V, Rizzoli SO.
    A Reliable Approach for Revealing Molecular Targets in Secondary Ion Mass Spectrometry.
    Int J Mol Sci. 2022 Apr 21;23(9):4615.doi: 10.3390/ijms23094615. PMID: 35563005. (PubMed)
  • Tayyeb A, Dihazi GH, Tampe B, Zeisberg M, Tampe D, Hakroush S, Bührig C, Frese J, Serin N, Eltoweissy M, Müller GA, Dihazi H.
    Calreticulin Shortage Results in Disturbance of Calcium Storage, Mitochondrial Disease, and Kidney Injury.
    Cells. 2022 Apr 13;11(8):1329. doi: 10.3390/cells11081329. PMID: 35456008. (PubMed)
  • Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA.
    α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
    Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30. PMID: 35353605. (PubMed)
  • Ding Y, Korchak S, Mamone, S, Jagtap AP, Stevanato G, Sternkoopf S, Moll D, Schroeder H, Becker S, Fischer A, Gerhardt E, Outeiro TF, Opazo F, Griesinger C, Glöggler S.
    Rapidly Signal-enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance.
    Chem Methods. 2022 doi:10.1002/ cmtd.202200023. (chemistry-europe)
  • Peña-Díaz S, Pujols J, Vasili E, Pinheiro F, Santos J, Manglano-Artuñedo Z, Outeiro TF, Ventura S.
    The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.
    J Biol Chem. 2022 Apr 4;298(5):101902. doi: 10.1016/j.jbc.2022.101902. Online ahead of print. PMID: 35390347. (PubMed)
  • strong>Dankovich TM, Rizzoli SO.
    Extracellular Matrix Recycling as a Novel Plasticity Mechanism With a Potential Role in Disease.
    Front Cell Neurosci. 2022 Mar 31;16:854897.doi: 10.3389/fncel.2022.854897. PMID: 35431813. (PubMed)
  • Vogl C, Neef J, Wichmann C.
    Methods for multiscale structural and functional analysis of the mammalian cochlea.
    Mol Cell Neurosci. 2022 Mar 11;120:103720. doi: 10.1016/j.mcn.2022.103720. PMID: 35288271. (PubMed)
  • Dankovich TM, Rizzoli SO.
    The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic.
    Front Synaptic Neurosci. 2022 Mar 8;14:854956. doi: 10.3389/fnsyn.2022.854956. PMID: 35350469. (PubMed)
  • Meschkat M, Steyer AM, Weil MT, Kusch K, Jahn O, Piepkorn L, Agüi-Gonzalez P, Phan NTN, Ruhwedel T, Sadowski B, Rizzoli SO, Werner HB, Ehrenreich H, Nave KA, Möbius W.
    White matter integrity in mice requires continuous myelin synthesis at the inner tongue.
    Nat Commun. 2022 Mar 4;13(1):1163. doi: 10.1038/s41467-022-28720-y. PMID: 35246535. (PubMed)
  • Hosang L, Cugota Canals R, van der Flier FJ, Hollensteiner J, Daniel R, Flügel A, Odoardi F.
    The lung microbiome regulates brain autoimmunity.
    Nature. 2022 Mar;603(7899):138-144. doi: 10.1038/s41586-022-04427-4. Epub 2022 Feb 23. PMID: 35197636. (PubMed)
  • Wegner W, Steffens H, Gregor C, Wolf F, Willig KI.
    Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy.
    Elife. 2022 Feb 23;11:e73603.doi: 10.7554/eLife.73603. PMID: 35195066. (PubMed)
  • Torres-Garcia L, P Domingues JM, Brandi E, Haikal C, Mudannayake JM, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li JY.
    Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.
    Sci Rep. 2022 Feb 22;12(1):2987. doi: 10.1038/s41598-022-06846-9. PMID: 35194057. (PubMed)
  • Al-Azzani M, König A, Outeiro TF.
    Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight.
    Biomolecules. 2022 Feb 18;12(2):324.doi: 10.3390/biom12020324. PMID: 35204823. (PubMed)
  • Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro T.
    Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells.
    Mol Neurobiol. 2022 Feb;59(2):1273-1284.doi: 10.1007/s12035-021-02713-2. Epub 2022 Jan 4. PMID: 34984585. (PubMed)
  • Zhang C, Hofmann D, Neef A, Wolf F.
    Ultrafast population coding and axo-somatic compartmentalization.
    PLoS Comput Biol. 2022 Jan 18;18(1):e1009775.doi: 10.1371/journal.pcbi.1009775. eCollection 2022 Jan. PMID: 35041645. (PubMed)
  • Oleksiievets N, Sargsyan Y, Thiele JC, Mougios N, Sograte-Idrissi S, Nevskyi O,Gregor I, Opazo F, Thoms S, Enderlein J, Tsukanov R.
    Fluorescence lifetime DNA-PAINT for multiplexed super-resolution imaging of cells.
    Commun Biol. 2022 Jan 11;5(1):38.doi: 10.1038/s42003-021-02976-4. PMID: 35017652 (PubMed)
  • Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J, International DLB Genetics Consortium; Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D.
    Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
    Brain. 2022 Jan 6;awac002.doi: 10.1093/brain/awac002. Online ahead of print. PMID: 34999780. (PubMed)

2021

  • Martins Merino R, Leon-Pinzon C, Stühmer W, Möck M, Staiger JF, Wolf F, Neef A.
    Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons.
    Proc Natl Acad Sci USA. 2021 Dec 21;118(51):e2114549118. doi: 10.1073/pnas.2114549118 (PubMed)
  • Dankovich TM, Kaushik R, Olsthoorn LHM, Petersen GC, Giro PE, Kluever V, Agüi-Gonzalez P, Grewe K, Bao G, Beuermann S, Hadi HA, Doeren J, Klöppner S, Cooper BH, Dityatev A, Rizzoli SO.
    Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R.
    Nat Commun. 2021 Dec 8;12(1):7129. doi: 10.1038/s41467-021-27462-7 (PubMed)
  • Wong-Guerra M, Montano-Peguero Y, Ramírez-Sánchez J, Jiménez-Martin J, Fonseca-Fonseca LA, Hernández-Enseñat D, Nonose Y, Valdés O, Mondelo-Rodriguez A, Ortiz-Miranda Y, Bergado G, Carmenate T, Soto Del Valle RM, Pardo-Andreu G, Outeiro TF, Padrón-Yaquis AS, Martimbianco de Assis A, O Souza D, Nuñez-Figueredo Y.
    JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats.
    Neurotoxicology. 2021 Dec;87:70-85. doi: 10.1016/j.neuro.2021.08.017. Epub 2021 Sep 2. (PubMed)
  • Nyamsuren G, Rapp G, Dihazi H, Zeisberg EM, Tampe D, Tampe B, Zeisberg M.
    PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation.
    Sci Rep. 2021 Dec 15;11(1):24075.doi: 10.1038/s41598-021-03523-1. (PubMed)
  • Hülskötter K, Jin W, Allnoch L, Hansmann F, Schmidtke D, Rohn K, Flügel A, Lühder F, Baumgärtner W, Herder V.
    Double-edged effects of tamoxifen-in-oil-gavage on an infectious murine model for multiple sclerosis.
    Brain Pathol. 2021 Nov;31(6):e12994. doi: 10.1111/bpa.12994. Epub 2021 Jun 17. PMID: 34137105. (PubMed)
  • Wichmann C, Kuner T.
    Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences.
    Physiological Reviews, 2021 November 2nd ;102(1):269-318. doi: 10.1152/physrev.00039.2020. (PubMed)
  • Dihazi A, Naamani K, Nabgui A, El Meziane A, Elmodafar C, Dihazi H.
    Proteome analysis of an aggressive and a hypoaggressive isolates of Fusarium oxysporum f. sp albedinis showing several differently expressed-proteins related to the aggressiveness.
    Physiol Mol. Plant Pathol.2021 in press. doi.org/10.1016/j.pmpp.2021.101738 (Sciencedirect)
  • Berghoff SA, Spieth L, Sun T, Hosang L, Depp C, Sasmita AO, Vasileva MH, Scholz P, Zhao Y, Krueger-Burg D, Wichert S, Brown ER, Michail K, Nave K-A, Bonn S, Odoardi F, Rossner M, Ischebeck T, Edgar JM, Saher G.
    Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice.
    Cell Rep. 2021 Oct 26;37(4):109889. doi.org/10.1016/j.celrep.2021.109889. PMID: 34706227. (PubMed)
  • Markworth R, Dambeck V, Steinbeck LM, Koufali A, Bues B, Dankovich TM, Wichmann C, Burk K.
    Tubular microdomains of Rab7-positive endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth disease 2B.
    J Cell Sci. 2021 Oct 15;134(20):jcs258559. doi: 10.1242/jcs.258559. Epub 2021 Oct 28. (PubMed)
  • Noor A, Zafar S, Shafiq M, Younas N, Siegert A, Mann FA, Kruss S, Schmitz M, Dihazi H, Ferrer I, Zerr I.
    Molecular Profiles of Amyloid-β Proteoforms in Typical and Rapidly Progressive Alzheimer's Disease.
    Mol Neurobiol.2021 Oct 7.doi: 10.1007/s12035-021-02566-9. Online ahead of print. (PubMed)
  • Flores-León M, Lázaro DF, Shvachiy L, Krisko A, Outeiro TF.
    In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies.
    Biochim Biophys Acta Proteins Proteom. 2021 Oct;1869(10):140693. doi: 10.1016/j.bbapap.2021.140693. Epub 2021 Jul 5. (PubMed)
  • Butola T, Alvanos T, Hintze A , Koppensteiner P, Kleindienst D, Shigemoto R, Wichmann C, Moser T.
    RIM-Binding Protein 2 Organizes Ca 2+ Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse.
    Journal of Neuroscience, 2021 Sep 15;41(37):7742-7767. doi: 10.1523/JNEUROSCI.0586-21.2021. Epub 2021 Aug 5. (PubMed)
  • Helm MS, Dankovich TM, Mandad S, Rammner B, Jähne S, Salimi V, Koerbs C, Leibrandt R, Urlaub H, Schikorski T, Rizzoli SO.
    A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines.
    Nat Neurosci. 2021 Aug;24(8):1151-1162.doi: 10.1038/s41593-021-00874-w. Epub 2021 Jun 24. (PubMed)
  • Markworth R, Bähr M, Burk K.
    Held Up in Traffic-Defects in the Trafficking Machinery in Charcot-Marie-Tooth Disease.
    Front Mol Neurosci. 2021 Aug 16;14:695294. doi: 10.3389/fnmol.2021.695294. eCollection 2021. PMID: 34483837 Free PMC article. Review. (PubMed)
  • Hülskötter K, Lühder F, Flügel A, Herder V, Baumgärtner W.
    Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection.
    Int J Mol Sci. 2021 Aug 6;22(16):8486. doi: 10.3390/ijms22168486. PMID: 34445189. (PubMed)
  • Miranda HV, Szegő ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, LashuelHA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.
    Erratum to: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
    Brain. 2021 Jul 28;144(6):e58.doi: 10.1093/brain/awab175.PMID: 34100910 (PubMed)
  • Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF.
    Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.
    NPJ Parkinsons Dis. 2021 Jul 26;7(1):65. doi: 10.1038/s41531-021-00203-9. (PubMed)
  • Glowacki SK, Gomes de Castro MA, Yip KM, Asadpour O, Münchhalfen M, Engels N, Opazo F.
    A fluorescent probe for STED microscopy to study NIP-specific B cells.
    Analyst.2021 2021 Jul 26;146(15):4744-4747.doi: 10.1039/d1an00601k. (PubMed)
  • Agüi-Gonzalez P, Dankovich TM, Rizzoli SO, Phan NTN.
    Gold-Conjugated Nanobodies for Targeted Imaging Using High-Resolution Secondary Ion Mass Spectrometry.
    Nanomaterials. 2021 Jul 10;11(7):1797.doi: 10.3390/nano11071797. (PubMed)
  • Joppe KDN, Tatenhorst L, Caldi Gomes L, Zhang S, Parvaz M, Carboni E, Roser AE, El DeBakey H, Bähr M, Vogel-Mikuš K, Ip CW, Becker S, Zweckstetter M, Lingor P.
    Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils.
    J Neurochem.2021 Jun 27.doi: 10.1111/jnc.15461. Online ahead of print. (PubMed)
  • Martinez Hernandez A, Silbern I, Geffers I, Tatenhorst L, Becker S, Urlaub H, Zweckstetter M, Griesinger C, Eichele G.
    Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein.
    Front. Neurosci. 17 June 2021 doi.org/10.3389/fnins.2021.643391 . (Frontiers)
  • Steffens H, Mott AC, Li S, Wegner W, Švehla P, Kan VWY, Wolf F, Liebscher S, Willig KI.
    Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity.
    Sci Adv. 2021 Jun 9;7(24):eabf2806. doi: 10.1126/sciadv.abf2806. Print 2021 Jun. (PubMed)
  • Vahsen BF, Lingor P.
    ULK1 as a novel therapeutic target in neurodegeneration.
    Neural Regen Res. 2021 Jun;16(6):1212-1213. doi: 10.4103/1673-5374.300442. (PubMed)
  • Serin N, Dihazi GH, Tayyeb A, Lenz C, Müller GA, Zeisberg M, Dihazi H.
    Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development.
    Int. J. Mol. Sci. 2021 May 30;22(11):5858.doi: 10.3390/ijms22115858. (PubMed)
  • Lange F, Agüi-Gonzalez P, Riedel D, Phan NTN, Jakobs S, Rizzoli SO.
    Correlative fluorescence microscopy, transmission electron microscopy and secondary ion mass spectrometry (CLEM-SIMS) for cellular imaging
    PLoS One. 2021 May 10;16(5):e0240768.doi: 10.1371/journal.pone.0240768. eCollection 2021. (PubMed)
  • Agüi-Gonzalez P, Guobin B, Gomes de Castro MA, Rizzoli SO, Phan NTN.
    Secondary Ion Mass Spectrometry Imaging Reveals Changes in the Lipid Structure of the Plasma Membranes of Hippocampal Neurons following Drugs Affecting Neuronal Activity.
    ACS Chem Neurosci. 2021 May 5;12(9):1542-1551. doi: 10.1021/acschemneuro.1c00031. Epub 2021 Apr 26. (PubMed)
  • Koss DJ, Campesan S, Giorgini F, Outeiro TF.
    Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.
    Mov Disord. 2021 May 3. doi:10.1002/mds.28605. Epub ahead of print. (PubMed)
  • Saal KA, Warth Pérez Arias C, Roser AE, Christoph Koch J, Bähr M, Rizzoli SO, Lingor P.
    Rho-kinase inhibition by fasudil modulates pre-synaptic vesicle dynamics.
    J Neurochem. 2021 May;157(4):1052-1068. doi: 10.1111/jnc.15274. Epub 2021 Jan 6. (PubMed)
  • Outeiro TF.
    Alpha-synuclein oligomerization and aggregation: A model will always be a model: This is a response to "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". Read the reply on "Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model". The articles are accompanied by a Preface "How good are cellular models?".
    J Neurochem. 2021 May;157(4):889-890.doi: 10.1111/jnc.15264. Epub 2021 Feb 13. (PubMed)
  • Outeiro TF.
    Alpha-Synuclein Antibody Characterization: Why Semantics Matters.
    Neurobiol. 2021 May;58(5):2202-2203. doi: 10.1007/s12035-020-02269-7. Epub 2021 Jan 7. (PubMed)
  • Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M.
    Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo.
    Mol Ther. 2021 Apr 30:S1525-0016(21)00249-5. doi: 10.1016/j.ymthe.2021.04.035. Epub ahead of print. (PubMed)
  • Outeiro TF, Heutink P, Bezard E, Cenci AM.
    From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease.
    Mov Disord. 2021 Apr;36(4):832-841. doi: 10.1002/mds.28387. Epub 2020 Nov 16. (PubMed)
  • Popova B, Wang D, Rajavel A, Dhamotharan K, Lázaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH.
    Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation.
    Front Mol Neurosci. 2021 Apr 12;14:659926. doi: 10.3389/fnmol.2021.659926. (PubMed)
  • Erskine D, Koss D, Korolchuk VI, Outeiro TF.
    Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders.
    Acta Neuropathol. 2021 Apr;141(4):511-526. doi: 10.1007/s00401-021-02266-7. Epub 2021 Jan 30. (PubMed)
  • Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF.
    Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo.
    Neurobiol Dis. 2021 Apr;151:105256. doi: 10.1016/j.nbd.2021.105256. Epub 2021 Jan 8. (PubMed)
  • Outeiro TF.
    Emerging concepts in synucleinopathies.
    Acta Neuropathol. 2021 Apr;141(4):469-470. doi: 10.1007/s00401-021-02290-7. Epub 2021 Feb 24. (PubMed)
  • Roggenkamp HG, Khansahib I, Hernandez LC, Zhang Y, Lodygin D, Krüger A, Gu F, Möckl F, Löhndorf A, Wolters V, Woike D, Rosche A, Bauche A, Schetelig D, Werner R, Schlüter H, Failla AV, Meier C, Fliegert R, Walseth TF, Flügel A, Diercks BP, Guse AH.
    HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation.
    Sci Signal. 2021 Mar 23;14(675):eabd5647. doi: 10.1126/scisignal.abd5647. PMID: 33758062. (PubMed)
  • Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB.
    Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity.
    Front Aging Neurosci. 2021 Mar 22;13:635760. doi: 10.3389/fnagi.2021.635760. (PubMed)
  • Jacinto S, Guerreiro P, de Oliveira RM, Cunha-Oliveira T, Santos MJ, Grazina M, Rego AC, Outeiro TF.
    MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile.
    Front Cell Neurosci. 2021 Mar 17;15:641264. doi:10.3389/fncel.2021.641264. (PubMed)
  • Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V.
    Presynaptic activity and protein turnover are correlated at the single-synapse level.
    Cell Rep. 2021 Mar 16;34(11):108841.doi: 10.1016/j.celrep.2021.108841. (PubMed)
  • Dihazi H, Schwarze K , Patschan S, Müller GA, Ritter O, Zeisberg M, Patschan D.
    PAC-Mediated AKI Protection Is Critically Mediated but Does Not Exclusively Depend on Cell-Derived Microvesicles.
    Int. J. Nephrol. 2021 Mar 9;2021:8864183.doi: 10.1155/2021/8864183. eCollection 2021. (PubMed)
  • Reshetniak S, Rizzoli SO.
    The vesicle cluster as a major organizer of synaptic composition in the short-term and long-term.
    Curr Opin Cell Biol. 2021 Mar 8;71:63-68. doi: 10.1016/j.ceb.2021.02.007. Online ahead of print. (PubMed)
  • Hintze A, Gültas M, Semmelhack EA, Wichmann C.
    Ultrastructural maturation of the endbulb of Held active zones comparing wild-type and otoferlin-deficient mice.
    i.Science. 2021 Mar 8;24(4):102282.doi: 10.1016/j.isci.2021.102282. eCollection 2021 Apr 23. (PubMed)
  • Popova B, Wang D, Pätz C, Akkermann D, Lázaro DF, Galka D, Kolog Gulko M, Bohnsack MT, Möbius W, Bohnsack KE, Outeiro TF, Braus GH.
    DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
    PLoS Genet. 2021 Mar 3;17(3):e1009407. doi: 10.1371/journal.pgen.1009407. (PubMed)
  • Winkler A, Wrzos C, Haberl M, Weil MT, Gao M, Möbius W, Odoardi F, Thal DR, Chang M, Opdenakker G, Bennett JL, Nessler S, Stadelmann C.
    Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration.
    J Clin Invest 2021 Mar 1;131(5):e141694.doi: 10.1172/JCI141694. (PubMed)
  • Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V , Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M.
    Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
    Nat Neurosci. 2021 Mar;24(3):355-367. doi: 10.1038/s41593-020-00780-7. Epub 2021 Jan 25. (PubMed)
  • Ribas VT, Vahsen BF, Tatenhorst L, Estrada V, Dambeck V, Alves Almeida R, Bähr M, Michel U, Koch JC, Müller HW, Lingor P.
    AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo.
    Cell Death Dis. 2021 Feb 26;12(2):213.doi: 10.1038/s41419-021-03503-3. (PubMed)
  • Kilisch M, Götzke H, Gere-Becker M, Crauel A, Opazo F, Frey S.
    Discovery and Characterization of an ALFA-Tag-Specific Affinity Resin Optimized for Protein Purification at Low Temperatures in Physiological Buffer.
    Biomolecules. 2021 Feb 12;11(2):269. doi: 10.3390/biom11020269. (PubMed)
  • Brás IC, Outeiro TF.
    Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies.
    Cells. 2021 Feb 12;10(2):375. doi:10.3390/cells10020375. (PubMed)
  • Löhndorf A, Hosang L, Dohle W, Odoardi F, Waschkowski S-A, Rosche A, Bauche A, Winzer R, Tolosa E, Windhorst S, Marry S, Flügel A, Potter BVL, Diercks B-P, Guse AH.
    2-Methoxyestradiol and its derivatives inhibit store-operated Ca 2+ entry in T cells: Identification of a new and potent inhibitor.
    Biochim Biophys Acta Mol Cell Res. 2021 Feb 10;1868(6):118988.doi: 10.1016/j.bbamcr.2021.118988. Epub 2021 Feb 10. (PubMed)
  • Dankovich TM, Rizzoli SO.
    Challenges facing quantitative large-scale optical super-resolution, and some simple solutions.
    iScience. 2021 Feb 3;24(3):102134. doi: 10.1016/j.isci.2021.102134. (PubMed)
  • Outeiro TF, Krisko A.
    Reply to: "Parkinson's Disease and COVID-19: Do We Need to Be More Patient?".
    Mov Disord. 2021 Feb;36(2):278-279.doi: 10.1002/mds.28482. (PubMed)
  • Filippou PS, Outeiro TF.
    Cancer and Parkinson's Disease: Common Targets, Emerging Hopes.
    Mov Disord. 2021 Feb;36(2):340-346. doi: 10.1002/mds.28425. Epub 2020 Dec 21. (PubMed)
  • Bonnin EA, Fornasiero EF, Lange F, Turck CW, Rizzoli SO.
    NanoSIMS observations of mouse retinal cells reveal strict metabolic controls on nitrogen turnover.
    BMC Mol Cell Biol. 2021 Jan 11;22(1):5. doi: 10.1186/s12860-020-00339-1. Epub 2020 Dec 21. (PubMed)
  • Berghoff SA, Spieth L, Sun T,Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G.
    Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
    Nat Neurosci 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. (PubMed)
  • Truckenbrodt S, Rizzoli SO.
    Simple multi-color super-resolution by X10 microscopy.
    Methods Cell Biol.2021;161:33-56. doi: 10.1016/bs.mcb.2020.04.016. Epub 2020 May 27. (PubMed)
  • Klionsky DJ, ...Lingor P, ... Outeiro TF, ... Tong CK.
    Guidelines for the use and interpretation of assays for monitoring autophagy.
    Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. (PubMed)
  • Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y.
    JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
    Neurotoxicology. 2021 Jan;82:89-98. doi: 10.1016/j.neuro.2020.11.005. Epub 2020 Nov 21. (PubMed)

2020

  • Sograte-Idrissi S, Schlichthaerle T, Duque-Afonso CJ, Alevra M, Strauss S, Moser T, Jungmann R, Rizzoli SO, Opazo F.
    Correction: Circumvention of common labelling artefacts using secondary nanobodies.
    Nanoscale. 2020 Dec 23;12(48):24543. doi: 10.1039/d0nr90279a. (PubMed)
  • Perego E, Reshetniak S, Lorenz C, Hoffmann C, Milovanović D, Rizzoli SO, Köster S.
    A minimalist model to measure interactions between proteins and synaptic vesicles.
    Sci Rep. 2020 Dec 3;10(1):21086. doi: 10.1038/s41598-020-77887-1. (PubMed)
  • Dominguez-Meijide A, Vasili E, Outeiro TF.
    Pharmacological Modulators of Tau Aggregation and Spreading.
    Brain Sci. 2020 Nov 13;10(11):858.doi: 10.3390/brainsci10110858. (PubMed)
  • Korchak S, Jagtap A, Glöggler S.
    Signal-enhanced real-time magnetic resonance of enzymatic reactions at millitesla fields.
    Chem. Sci. 2020 Oct DOI: 10.1039/d0sc04884d. (pubs.rsc)
  • Hentrich T, Wassouf Z, Ehrhardt C, Haas E, Mills JD, Aronica E, Outeiro TF, Hübener-Schmid J, Riess O, Casadei N, Schulze-Hentrich JM.
    Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients.
    Aging (Albany NY). 2020 Oct 5;12(19):18889-18906. doi: 10.18632/aging.103935. Online ahead of print. (PubMed)
  • Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff C.
    Quantitative Synaptic Biology: A Perspective on Techniques, Numbers and Expectations.
    Int J Mol Sci. 2020 Oct 2;21(19):7298. doi: 10.3390/ijms21197298 (PubMed)
  • Domingues R, Lippi A, Setz C, Outeiro TF, Krisko A.
    SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime.
    Aging (Albany NY). 2020 Sep 29;12(18):18778-18789.doi: 10.18632/aging.103989. Online ahead of print. (PubMed)
  • Pasterkamp RJ, Burk K.
    Axon guidance receptors: Endocytosis, trafficking and downstream signaling from endosomes.
    Prog Neurobiol. 2020 Sep 28:101916. doi: 10.1016/j.pneurobio.2020.101916. Epub ahead of print. (PubMed)
  • Lipphardt M, Dihazi H, Maas JH, Schäfer AK, Amlaz SI, Ratliff BB, Koziolek MJ, Wallbach M.
    Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.
    J. Clin.Med. 2020 Sep 22;9(9):3051.doi: 10.3390/jcm9093051.PMID: 32971813 (PubMed)
  • Mamone S, Schmidt AB, Schwaderlapp N, Lange T, von Elverfeldt D, Hennig J, Glöggler S.
    Localized singlet-filtered MRS in vivo.
    NMR Biomed. 2020 Sep 1;e4400. doi: 10.1002/nbm.4400. Online ahead of print. (PubMed)
  • Menezes R, Foito A, Jardim C, Costa I, Garcia G, Rosado-Ramos R, Freitag S, Alexander CJ, Outeiro TF, Stewart D, Santos CN.
    Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases.
    Antioxidants (Basel). 2020 Aug 26;9(9):789.doi: 10.3390/antiox9090789. (PubMed)
  • Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF , Schüle B.
    The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders.
    Review, Int J Mol Sci. 2020 Aug 10;21(16):5724.doi: 10.3390/ijms21165724. (PubMed)
  • Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF.
    RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies.
    Brain Pathol. 2020 Aug 6.doi: 10.1111/bpa.12890. Online ahead of print. (PubMed)
  • Harris SS, Wolf F, De Strooper B, Busche MA.
    Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease.
    Neuron. 2020 Aug 5;107(3):417-435.doi: 10.1016/j.neuron.2020.06.005. Epub 2020 Jun 23. (PubMed)
  • Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF.
    Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
    Sci Rep. 2020 Jul 30;10(1):12827.doi: 10.1038/s41598-020-69744-y. (PubMed)
  • Bonnin EA, Rizzoli SO.
    Novel Secondary Ion Mass Spectrometry Methods for the Examination of Metabolic Effects at the Cellular and Subcellular Levels.
    Front Behav Neurosci.2020 Jul 20;14:124.doi: 10.3389/fnbeh.2020.00124. eCollection 2020. (PubMed)
  • Dihazi GH, Eltoweissy M, Jahn O, Tampe B, Zeisberg M, Wülfrath HS, Müller GA, Dihazi H.
    The Secretome Analysis of Activated Human Renal Fibroblasts Revealed Beneficial Effect of the Modulation of the Secreted Peptidyl-Prolyl Cis-Trans Isomerase A in Kidney Fibrosis.
    Cells. 2020 Jul 18;9(7):1724.doi: 10.3390/cells9071724. PMID:32708451;PMC7407823 (PubMed)
  • Mann FA, Herrmann N, Opazo F, Kruss S.
    Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins.
    Angew Chem Int Ed Engl 2020 Sep 28;59(40):17732-17738. doi: 10.1002/anie.202003825. Epub 2020 Jul 13. (PubMed)
  • Belo RF, Martins MLF, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, Neves V, Vicente Miranda H, Outeiro TF, Coelho JE, Xapelli S, Valente CA, Heras M, Bardaji E, Castanho MARB, Diógenes MJ, Sebastião AM.
    The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.
    Front Pharmacol. 2020 Jul 9;11:985.doi: 10.3389/fphar.2020.00985. eCollection 2020. (PubMed)
  • Sato M, Mizuta K, Islam T, Kawano M, Sekine Y, Takekawa T, Gomez-Dominguez D, Schmidt A, Wolf F, Kim K, Yamakawa H, Ohkura M, Lee MG, Fukai T, Nakai J, Hayashi Y.
    Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.
    Cell Rep. 2020 Jul 7;32(1):107864.doi: 10.1016/j.celrep.2020.107864. (PubMed)
  • Reshetniak S, Ußling JE, Perego E, Rammner B, Schikorski T, Fornasiero EF, Truckenbrodt S, Köster S, Rizzoli SO.
    A comparative analysis of the mobility of 45 proteins in the synaptic bouton.
    EMBO J. 2020 Aug 17;39(16):e104596.doi: 10.15252/embj.2020104596. (PubMed)
  • Schilde LM, Steinbach S, Serschnitzki B, Maass F, Bähr M, Lingor P, Marcus K, May C.
    Human cerebrospinal fluid data for use as spectral library, for biomarker research
    Data Brief. 2020 Jul 19;32:106048.doi: 10.1016/j.dib.2020.106048. eCollection 2020 Oct. (PubMed)
  • Outeiro TF, Krisko A.
    Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases
    Mov Disord. 2020 Jul;35(7):1106-1107.doi: 10.1002/mds.28178. (PubMed)
  • Joppe K, Nicolas JD, Grünewald TA, Eckermann M, Salditt T, Lingor P.
    Elemental quantification and analysis of structural abnormalities in neurons from Parkinson's-diseased brains by X-ray fluorescence microscopy and diffraction.
    Biomed Opt Express. 2020 Jun 2;11(7):3423-3443. doi: 10.1364/BOE.389408. eCollection 2020 Jul 1. (PubMed)
  • JeJean P, Anttonen T, Michanski S, de Diego AMG, Steyer AM, Neef A, Oestreicher D, Kroll J, Nardis N, Pangršič T, Möbius W, Ashmore J, Wichmann C, Moser T.
    Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
    Nat Commun. 2020 Jun 25;11(1):3208. doi: 10.1038/s41467-020-17003-z.  (PubMed)
  • Gerdes C, Waal N, Offner T, Fornasiero EF, Wender N, Verbarg H, Manzini I, Trenkwalder C, Mollenhauer B, Strohäker T, Zweckstetter M, Becker S, Rizzoli SO, Basmanav FB, Opazo F.
    A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol
    Nat Commun. 2020 Jun 1;11(1):2729.doi: 10.1038/s41467-020-16575-0. (PubMed)
  • Maass F, Rikker S, Dambeck V, Warth C, Tatenhorst L, Csoti I, Schmitz M, Zerr I, Leha A, Bähr M, Lingor P.
    Increased alpha-synuclein tear fluid levels in patients with Parkinson’s disease.
    Sci Rep.2020 May 22;10(1):8507.doi: 10.1038/s41598-020-65503-1. (PubMed)
  • Santos PI, Outeiro TF.
    Protein trapping leads to altered synaptic proteostasis in synucleinopathies.
    Review, FEBS J. 2020 May 13.doi: 10.1111/febs.15364. Online ahead of print. (PubMed)
  • Cukierman DS, Lázaro DF, Sacco P, Ferreira PR, Diniz R, Fernández CO, Outeiro TF, Rey NA.
    X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(i)/copper(ii)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy.
    Dalton Trans. 2020 May 11.doi: 10.1039/d0dt01138j. Online ahead of print. (PubMed)
  • Brás IC, Dominguez-Meijide A, Gerhardt E, Koss D, Lázaro DF, Santos PI, Vasili E, Xylaki M, Outeiro TF.
    Synucleinopathies: Where we are and where we need to go.
    Review Neurochem. 2020 May;153(4):433-454.doi: 10.1111/jnc.14965. Epub 2020 Feb 19. (PubMed)
  • Vicente Miranda H, Chegão A, Oliveira MS, Fernandes Gomes B, Enguita FJ, Outeiro TF.
    Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein.
    FASEB J. 2020 May;34(5):6718-6728.doi: 10.1096/fj.201902936R. Epub 2020 Apr 7. (PubMed)
  • Vahsen BF, Ribas VT, Sundermeyer J, Boecker A, Dambeck V, Lenz C, Shomroni O, Caldi Gomes L, Tatenhorst L, Barski E, Roser AE, Michel U, Urlaub H, Salinas G, Bähr M, Koch JC, Lingor P.
    Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in Vivo, enhances translation, and modulates splicing.
    Cell Death Differ. 2020 Apr 27. doi: 10.1038/s41418-020-0543-y. Online ahead of print. (PubMed)
  • Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A.
    SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration.
    Mov Disord. 2020 May;35(5):716-720.doi: 10.1002/mds.28084. Epub 2020 Apr 24. (PubMed)
  • Lázaro DF, Outeiro TF.
    The Interplay Between Proteostasis Systems and Parkinson's Disease.
    Review, Adv Exp Med Biol. 2020;1233:223-236.doi: 10.1007/978-3-030-38266-7_9. (PubMed)
  • Francelle L, Outeiro TF, Rappold GA.
    Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity.
    Sci Rep. 2020 Apr 8;10(1):6064.doi: 10.1038/s41598-020-62678-5. (PubMed)
  • Vale N , Alves C, Sharma V, Lázaro DF, Silva S, Gomes P, Outeiro TF.
    A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
    Pharmacol Rep. 2020 Apr;72(2):456-464.doi: 10.1007/s43440-019-00032-x. Epub 2020 Jan 15. (PubMed)
  • Maus L, Lee C, Altas B, Sertel SM, Weyand K, Rizzoli SO, Rhee J, Brose N, Imig C, Cooper BH.
    Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.
    Cell Rep. 2020 Mar 17;30(11):3632-3643.e8. doi: 10.1016/j.celrep.2020.02.083. (PubMed)
  • Brás IC, Xylaki M, Outeiro TF.
    Mechanisms of alpha-synuclein toxicity: An update and outlook.
    Prog Brain Res. 2020;252:91-129.doi: 10.1016/bs.pbr.2019.10.005. Epub 2019 Nov 23. (PubMed)
  • Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ.
    Are genetic and idiopathic forms of Parkinson’s disease the same disease?
    J Neurochem. 2020 Mar;152(5):515-522. doi: 10.1111/jnc.14902. Epub 2019 Dec 8. Review. (PubMed)
  • Koziolek M, Mueller GA, Dihazi GH, Jung K, Altubar C, Wallbach M, Markovic I, Raddatz D, Jahn O, Karaköse H, Lenz C, Urlaub H, Dihazi A, El Meziane A, Dihazi H.
    Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients.
    J Clin Med. 2020 Feb 27;9(3). pii: E639. doi: 10.3390/jcm9030639. (PubMed)
  • Mamone S, Rezaei-Ghaleh N, Opazo F, Griesinger C, Glöggler S.
    Singlet-filtered NMR spectroscopy
    Science Advances 21 Feb 2020: Vol. 6, no. 8, eaaz1955. DOI: 10.1126/sciadv.aaz1955
  • Outeiro TF.
    The courage to change science.
    EMBO Rep. 2020 Mar 4;21(3):e50124.doi: 10.15252/embr.202050124. Epub 2020 Feb 20. (PubMed)
  • Balke D, Tatenhorst L, Dambeck V, Ribas VT, Vahsen BF, Michel U, Bähr M, Lingor P.
    AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson’s Disease.
    Mol Neurobiol. 2020 Feb;57(2):685-697. doi: 10.1007/s12035-019-01744-0. Epub 2019 Aug 24. (PubMed)
  • Maass F, Michalke B, Willkommen D, Leha A, Schulte C, Tönges L, Mollenhauer B, Trenkwalder C, Rückamp D, Börger M, Zerr I, Bähr M, Lingor P.
    Elemental fingerprint: Reassessment of a cerebrospinal fluid biomarker for Parkinson’s disease.
    Neurobiol Dis. 2020 Feb;134:104677. doi: 10.1016/j.nbd.2019.104677. Epub 2019 Nov 13. (PubMed)
  • Vaz RL, Sousa S, Chapela D, van der Linde HC, Willemsen R, Correia AD, Outeiro TF, Afonso ND..
    Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model.
    Pharmacol Biochem Behav. 2020 Feb;189:172828. doi: 10.1016/j.pbb.2019.172828. Epub 2019 Nov 28. (PubMed)
  • Kroll J, Özçete ÖD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T.
    AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
    J Cell Sci. 2020 Jan 22;133(2). pii: jcs236737. doi: 10.1242/jcs.236737. (PubMed)
  • Brás IC, Dominguez-Meijide A, Gerhardt E, Koss D, Lázaro DF, Santos PI, Vasili E, Xylaki M, Outeiro TF.
    Synucleinopathies: Where we are and where we need to go.
    J Neurochem. 2020 Jan 20. doi: 10.1111/jnc.14965. [Epub ahead of print] (PubMed)
  • Vale N, Alves C, Sharma V, Lázaro DF, Silva S, Gomes P, Outeiro TF.
    A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.
    Pharmacol Rep. 2020 Jan 15. doi: 10.1007/s43440-019-00032-x. [Epub ahead of print] (PubMed)
  • Vaz RL, Chapela D, Coelho JE, Lopes LV, Ferreira JJ, Afonso ND, Sousa S, Outeiro TF.
    Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.
    Neuroscience. 2020 Jan 1;424:58-71. doi: 10.1016/j.neuroscience.2019.08.046. Epub 2019 Nov 1. (PubMed)
  • Masaracchia C, König A, Valiente-Gabioud AA, Peralta P, Favretto F, Strohäker T, Lázaro DF, Zweckstetter M, Fernandez CO, Outeiro TF.
    Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.
    Biochim Biophys Acta Proteins Proteom. 2020 Jan;1868(1):140298. doi: 10.1016/j.bbapap.2019.140298. Epub 2019 Oct 30. (PubMed)
  • Lázaro DF, Bellucci A, Brundin P, Outeiro TF.
    Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases.
    Editorial, Front Mol Neurosci. 2020 Jan 17;12:312.doi: 10.3389/fnmol.2019.00312. eCollection 2019. (PubMed)
  • Maass F, Michalke B, Willkommen D, Schulte C, Tönges L, Boerger M, Zerr I, Bähr M, Lingor P.
    Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson’s disease.
    J Trace Elem Med Biol. 2020 Jan;57:126412. doi: 10.1016/j.jtemb.2019.126412. Epub 2019 Sep 24. (PubMed)

2019

  • Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gärtner A, Kügler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF.
    The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.
    Sci Adv. 2019 Dec 18;5(12):eaay2670. doi: 10.1126/sciadv.aay2670. eCollection 2019 Dec. (PubMed)
  • Brasil AA, de Carvalho MDC, Gerhardt E, Queiroz DD, Pereira MD, Outeiro TF, Eleutherio ECA.
    Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1.
    Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25991-26000. doi: 10.1073/pnas.1902483116. Epub 2019 Dec 3. (PubMed)
  • Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF.
    A mass spectrometry workflow for measuring protein turnover rates in vivo.
    Nat Protoc. 2019 Dec;14(12):3333-3365. doi: 10.1038/s41596-019-0222-y. Epub 2019 Nov 4. (PubMed)
  • Revah O, Stoler O, Neef A, Wolf F, Fleidervish IA, Gutnick MJ.
    Dynamic Gain Analysis Reveals Encoding Deficiencies in Cortical Neurons That Recover from Hypoxia-Induced Spreading Depolarizations.
    J Neurosci. 2019 Sep 25;39(39):7790-7800.doi: 10.1523/JNEUROSCI.3147-18.2019. Epub 2019 Aug 9. . (PubMed)
  • Hoffmann JC, Patschan D, Dihazi H, Müller C, Schwarze K, Henze E, Ritter O, Müller GA, Patschan S.
    Cytokine profiling in anti neutrophil cytoplasmic antibody-associated vasculitis: a cross-sectional cohort study.
    Rheumatol Int. 2019 Nov;39(11):1907-1917. doi: 10.1007/s00296-019-04364-y. Epub 2019 Jul 8. (PubMed)
  • Korchak S, Emondts M, Mamone S, Blümich B, Glöggler S.
    Production of highly concentrated and hyperpolarized metabolites within seconds in high and low magnetic fields.
    Phys Chem Chem Phys. 2019 Oct 24;21(41):22849-22856. doi: 10.1039/c9cp05227e. (PubMed)
  • Valerius O, Asif AR, Beißbarth T, Bohrer R, Dihazi H, Feussner K, Jahn O, Majcherczyk A, Schmidt B, Schmitt K, Urlaub H, Lenz C.
    Mapping Cellular Microenvironments: Proximity Labeling and Complexome Profiling (Seventh Symposium of the Göttingen Proteomics Forum).
    Cells. 2019 Oct 2;8(10). pii: E1192. doi: 10.3390/cells8101192. (PubMed)
  • Götzke H, Kilisch M, Martínez-Carranza M, Sograte-Idrissi S, Rajavel A, Schlichthaerle T, Engels N, Jungmann R, Stenmark P, Opazo F, Frey S.
    The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications.
    Nat Commun. 2019 Sep 27;10(1):4403. doi: 10.1038/s41467-019-12301-7. (PubMed)
  • Outeiro TF, Mestre TA.
    Synuclein Meeting 2019: where we are and where we need to go.
    J Neurochem. 2019 Sep;150(5):462-466. doi: 10.1111/jnc.14825. (PubMed)
  • Xylaki M, Atzler B, Outeiro TF.
    Epigenetics of the Synapse in Neurodegeneration.
    Curr Neurol Neurosci Rep. 2019 Aug 23;19(10):72. doi: 10.1007/s11910-019-0995-y. (PubMed)
  • Reshetniak S, Rizzoli SO.
    Interrogating Synaptic Architecture: Approaches for Labeling Organelles and Cytoskeleton Components.
    Front Synaptic Neurosci. 2019 Aug 23;11:23. doi: 10.3389/fnsyn.2019.00023. eCollection 2019. (PubMed)
  • Mann FA, Lv Z, Großhans J, Opazo F, Kruss S.
    Nanobody-Conjugated Nanotubes for Targeted Near-Infrared In Vivo Imaging and Sensing.
    Angew Chem Int Ed Engl. 2019 Aug 12;58(33):11469-11473. doi: 10.1002/anie.201904167. Epub 2019 Jul 8. (PubMed)
  • Sampaio-Marques B, Guedes A, Vasilevskiy I, Gonçalves S, Outeiro TF, Winderickx J, Burhans WC, Ludovico P.
    α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1.
    Aging Cell. 2019 Aug;18(4):e12922. doi: 10.1111/acel.12922. Epub 2019 Apr 11. (PubMed)
  • Jagtap AP, Kaltschnee L, Glöggler S.
    Hyperpolarization of 15N-pyridinium and 15N-aniline derivatives by using parahydrogen: new opportunities to store nuclear spin polarization in aqueous media.
    Chem Sci. 2019 Aug 6;10(37):8577-8582. doi: 10.1039/c9sc02970b. eCollection 2019 Oct 7. (PubMed)
  • Ferreira C, Couceiro J, Família C, Jardim C, Antas P, Santos CN, Outeiro TF, Tenreiro S, Quintas A.
    The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism.
    FEMS Yeast Res. 2019 Aug 1;19(5). pii: foz042. doi: 10.1093/femsyr/foz042. (PubMed)
  • Markworth R, Adolfs Y, Dambeck V, Steinbeck LM, Lizé M, Pasterkamp RJ, Bähr M, Dean C, Burk K.
    Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling.
    J Neurosci. 2019 Jul 24;39(30):5842-5860. doi: 10.1523/JNEUROSCI.0027-19.2019. Epub 2019 May 23. (PubMed)
  • Paiva I, Carvalho K, Santos P, Cellai L, Pavlou MAS, Jain G, Gnad T, Pfeifer A, Vieau D, Fischer A, Buée L, Outeiro TF, Blum D.
    A2A R-induced transcriptional deregulation in astrocytes: An in vitro study.
    Glia. 2019 Jul 22. doi: 10.1002/glia.23688. [Epub ahead of print] (PubMed)
  • Brás IC, König A, Outeiro TF.
    Glycation in Huntington’s Disease: A Possible Modifier and Target for Intervention.
    J Huntingtons Dis. 2019 Jul 16. doi: 10.3233/JHD-190366. [Epub ahead of print] (PubMed)
  • Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M.
    A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria.
    J Mol Biol. 2019 Jul 12;431(15):2835-2851. doi: 10.1016/j.jmb.2019.05.015. Epub 2019 May 17. (PubMed)
  • Fornasiero EF, S.Rizzoli SO.
    Pathological changes are associated with shifts in the employment of synonymous codons at the transcriptome level.
    BMC Genomics. 2019 Jul 9;20(1):566. doi: 10.1186/s12864-019-5921-9. (PubMed)
  • Delenclos M, Burgess JD, Lamprokostopoulou A, Outeiro TF, Vekrellis K, McLean PJ.
    Cellular models of alpha-synuclein toxicity and aggregation.
    J Neurochem. 2019 Jul 2. doi: 10.1111/jnc.14806. [Epub ahead of print] (PubMed)
  • Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, Thom T, Rizzoli S, Schmitz M, Li J, Zerr I, Attems J, Jahn O, Outeiro TF.
    Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
    Cell Rep. 2019 Jul 2;28(1):65-77.e6. doi: 10.1016/j.celrep.2019.06.009. (PubMed)
  • Rossetti G, Kless A, Lai L, Outeiro TF, Carloni P.
    Investigating targets for neuropharmacological intervention by molecular dynamics simulations.
    Biochem Soc Trans. 2019 Jun 28;47(3):909-918. doi: 10.1042/BST20190048. Epub 2019 May 13. (PubMed)
  • Outeiro TF, Harvey K, Dominguez-Meijide A, Gerhardt E.
    LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?
    Biochem Soc Trans. 2019 Jun 28;47(3):827-838. doi: 10.1042/BST20180466. Epub 2019 May 13. (PubMed)
  • Kaltschnee L, Jagtap A, McCormick J, Bouchard L, Wagner S, Utz M, Griesinger C, Glöggler S.
    Hyperpolarization of Amino Acids in Water Utilizing Parahydrogen on a Rhodium Nanocatalyst.
    SFX-Linkservice der SUB Goettingen 25 June 2019. doi.org/10.1002/chem.201902878.
  • Richter KN, Patzelt C, Phan NTN, Rizzoli SO.
    Antibody-driven capture of synaptic vesicle proteins on the plasma membrane enables the analysis of their interactions with other synaptic proteins.
    Sci Rep. 2019 Jun 25;9(1):9231. doi: 10.1038/s41598-019-45729-4. (PubMed)
  • Berner S, Schmidt AB, Zimmermann M, Pravdivtsev AN, Glöggler S, Hennig J, Elverfeldt D, Hövener JB.
    SAMBADENA Hyperpolarization of 13C‐Succinate in an MRI: Singlet‐Triplet Mixing Causes Polarization Loss.
    SFX-Linkservice der SUB Goettingen 04 June 2019. doi.org/10.1002/open.201900139.
  • Elliot SJ, Kadeřáve P, Brown LJ, Sabba M, Glöggler S, O’Leary DJ, Brown RCD, Ferrage F, Levitt MH.
    Field-cycling long-lived-state NMR of 15N2 spin pairs.
    Molecular Physics 117 (7-8), pp. 861 – 867 (2019)
  • Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY.
    Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.
    Transl Neurodegener. 2019 Jun 15;8:18. doi: 10.1186/s40035-019-0159-7. eCollection 2019. (PubMed)
  • Burk K, Pasterkamp RJ.
    Disrupted neuronal trafficking in amyotrophic lateral sclerosis.
    Acta Neuropathol. 2019 Jun;137(6):859-877. doi: 10.1007/s00401-019-01964-7. Epub 2019 Feb 5. (PubMed)
  • Wallbach M, Tampe B, Dihazi H, Koziolek MJ.
    [Acute kidney injury: from creatinine to KIM‑1?]
    Internist (Berl). 2019 Jun;60(6):578-586. doi: 10.1007/s00108-019-0602-y. Review. German. (PubMed)
  • Markworth R, Adolfs Y, Dambeck V, Steinbeck LM, Lizé M, Pasterkamp RJ, Bähr M, Dean C, Burk K.
    Sensory axon growth requires spatiotemporal integration of CaSR and TrkB signalling.
    J Neurosci. 2019 May 23. pii: 0027-19. doi: 10.1523/JNEUROSCI.0027-19.2019. [Epub ahead of print] (PubMed)
  • Seitz KJ, Rizzoli SO.
    GFP nanobodies reveal recently-exocytosed pHluorin molecules.
    Sci Rep. 2019 May 23;9(1):7773. doi: 10.1038/s41598-019-44262-8. (PubMed)
  • González N, Arcos-López T, König A, Quintanar L, Menacho Márquez M, Outeiro TF, Fernández CO.
    Effects of alpha-synuclein post-translational modifications on metal binding.
    J Neurochem. 2019 May 16. doi: 10.1111/jnc.14721. [Epub ahead of print] (PubMed)
  • Stoldt S, Stephan T, Jans DC, Brüser C, Lange F, Keller-Findeisen J, Riedel D, Hell SW, Jakobs S.
    Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria.
    Proc Natl Acad Sci U S A. 2019 May 14;116(20):9853-9858. doi: 10.1073/pnas.1820364116. Epub 2019 Apr 26. (PubMed)
  • Gong J, Szego ÉM, Leonov A, Benito E, Becker S, Fischer A, Zweckstetter M, Outeiro T, Schneider A.
    Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism.
    J Neurosci. 2019 May 8;39(19):3752-3769. doi: 10.1523/JNEUROSCI.2070-18.2019. Epub 2019 Feb 22. (PubMed)
  • Candelise N, Schmitz M, Llorens F, Villar-Piqué A, Cramm M, Thom T, da Silva Correia SM, da Cunha JEG, Möbius W, Outeiro TF, Álvarez VG, Banchelli M, D’Andrea C, de Angelis M, Zafar S, Rabano A, Matteini P, Zerr I.
    Seeding variability of different alpha synuclein strains in synucleinopathies.
    Ann Neurol. 2019 May;85(5):691-703. doi: 10.1002/ana.25446. Epub 2019 Mar 27. (PubMed)
  • Agüi-Gonzalez P, Jähne S, Phan NTN. (2019)
    SIMS imaging in neuro- and cell biology.
    J Anal At Spectrom, DOI: 10.1039/C9JA00118B
  • Kabatas S, Agüi-Gonzalez P, Hinrichs R, Jähne S, Opazo F, Diederichsen U, Rizzoli SO, Phan NTN. (2019)
    Fluorinated nanobodies for targeted molecular imaging of biological samples using nanoscale secondary ion mass spectrometry.
    J Anal At Spectrom 34:1083-1087
  • Chakrabarti R, Wichmann C.
    Nanomachinery Organizing Release at Neuronal and Ribbon Synapses.
    Int J Mol Sci. 2019 Apr 30;20(9). pii: E2147. doi: 10.3390/ijms20092147. (PubMed)
  • Vasili E, Dominguez-Meijide A, Outeiro TF.
    Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.
    Front Mol Neurosci. 2019 Apr 25;12:107. doi: 10.3389/fnmol.2019.00107. eCollection 2019. (PubMed)
  • Carija A, Pinheiro F, Pujols J, Brás IC, Lázaro DF, Santambrogio C, Grandori R, Outeiro TF, Navarro S, Ventura S.
    Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity.
    Redox Biol. 2019 Apr;22:101135. doi: 10.1016/j.redox.2019.101135. Epub 2019 Feb 5. (PubMed)
  • Marvian AT, Koss DJ, Aliakbari F, Morshedi D, Outeiro TF.
    In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies.
    J Neurochem. 2019 Apr 20. doi: 10.1111/jnc.14707. [Epub ahead of print] (PubMed)
  • Michanski S, Smaluch K, Steyer AM, Chakrabarti R, Setz C, Oestreicher D, Fischer C, Möbius W, Moser T, Vogl C, Wichmann C.
    Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea.
    Proc Natl Acad Sci U S A. 2019 Mar 13. pii: 201812029. doi: 10.1073/pnas.1812029116. [Epub ahead of print] (PubMed)
  • Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG.
    A practical guide to optimization in X10 expansion microscopy.
    Nat Protoc. 2019 Mar;14(3):832-863. doi: 10.1038/s41596-018-0117-3. (PubMed)
  • Kabatas S, Agüi-Gonzalez P, Saal KA, Jähne S, Opazo F, Rizzoli SO, Phan NTN.
    Boron-Containing Probes for Non-optical High-Resolution Imaging of Biological Samples.
    Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3438-3443. doi: 10.1002/anie.201812032. Epub 2019 Feb 6. (PubMed)
  • Kroll J, Jaime Tobón LM, Vogl C, Neef J, Kondratiuk I, König M, Strenzke N, Wichmann C, Milosevic I, Moser T.
    Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells.
    EMBO J. 2019 Mar 1;38(5). pii: e100116. doi: 10.15252/embj.2018100116. Epub 2019 Feb 7. (PubMed)
  • Rink WM, Thomas F.
    De Novo Designed α-Helical Coiled-Coil Peptides as Scaffolds for Chemical Reactions.
    Chemistry. 2019 Feb 1;25(7):1665-1677. doi: 10.1002/chem.201802849. Epub 2018 Nov 28. (PubMed)
  • Maidorn M, Olichon A, Rizzoli SO, Opazo F.
    Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons.
    MAbs. 2019 Feb/Mar;11(2):305-321. doi: 10.1080/19420862.2018.1551675. Epub 2018 Dec 28. (PubMed)
  • Yang S, McCormick J, Mamone S, Bouchard LS, Glöggler S.
    Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Switch for Spin Singlet States.
    Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2879-2883. doi: 10.1002/anie.201814198. Epub 2019 Jan 28. (PubMed)
  • Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A.
    β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.
    Nature. 2019 Feb;566(7745):503-508. doi: 10.1038/s41586-019-0964-2. Epub 2019 Feb 20. (PubMed)
  • Gomes de Castro MA, Wildhagen H, Sograte-Idrissi S, Hitzing C, Binder M, Trepel M, Engels N, Opazo F.
    Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane.
    Nat Commun. 2019 Feb 18;10(1):820. doi: 10.1038/s41467-019-08677-1. (PubMed)
  • Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, Donaghy P, Morris C, Taylor JP, Thomas A, Attems J, McKeith I.
    Dementia with Lewy bodies: an update and outlook.
    Mol Neurodegener. 2019 Jan 21;14(1):5. doi: 10.1186/s13024-019-0306-8. (PubMed)
  • Sograte-Idrissi S, Oleksiievets N, Isbaner S, Eggert-Martinez M, Enderlein J, Tsukanov R, Opazo F.
    Nanobody Detection of Standard Fluorescent Proteins Enables Multi-Target DNA-PAINT with High Resolution and Minimal Displacement Errors.
    Cells. 2019 Jan 14;8(1). pii: E48. doi: 10.3390/cells8010048. (PubMed)
  • Glöggler S, Yang S, McCormick J, Mamone S, Bouchard LS.
    Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Spin Singlet State Switch.
    Angew Chem Int Ed Engl. 2019 Jan 10. doi: 10.1002/anie.201814198. [Epub ahead of print] (PubMed)
  • Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.
    Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.
    Hum Mol Genet. 2019 Jan 1;28(1):31-50. doi: 10.1093/hmg/ddy326. (PubMed)
  • Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL.
    Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding
    Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. Epub 2018 Nov 15. (PubMed)
  • Brás IC, Popova B, Braus GH, Outeiro TF.
    Yeast-Based Screens to Target Alpha-Synuclein Toxicity.
    Methods Mol Biol. 2019;1948:145-156. doi: 10.1007/978-1-4939-9124-2_12. (PubMed)
  • Saul P, Mamone S, Glöggler S.
    Nuclear spin singlet multimers (NUSIMERs) with long-lived singlet states.
    Chem. Sci. 10, 413-417 (2019)

2018

  • Lazarov E, Dannemeyer M , Feulner B, Enderlein J, Gutnick MJ, Wolf F, Neef A.
    An axon initial segment is required for temporal precision in action potential encoding by neuronal populations
    Sci Adv. 2018 Nov 28;4(11):eaau8621.doi: 10.1126/sciadv.aau8621. eCollection 2018 Nov. (PubMed)
  • Harvey K, Outeiro TF.
    The role of LRRK2 in cell signalling.
    Biochem Soc Trans. 2018 Dec 21. pii: BST20180464. doi: 10.1042/BST20180464. [Epub ahead of print] Review. (PubMed)
  • Saal K-A, Richter F, Rehling P, Rizzoli SO.
    Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry
    ACS Nano 2018 Dec 10 DOI:10.1021/acsnano.8b06047 [Epub ahead of print] (PubMed)
  • Brás IC, Tenreiro S, Silva AM, Outeiro TF.
    Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast.
    FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy108. (PubMed)
  • Brás IC, Lopes LV, Outeiro TF.
    Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration.
    Mov Disord. 2018 Nov;33(11):1675-1684. doi: 10.1002/mds.27478. Epub 2018 Nov 13. (PubMed)
  • Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF.
    Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
    Neurobiol Dis. 2018 Nov;119:121-135. doi: 10.1016/j.nbd.2018.08.001. Epub 2018 Aug 6. (PubMed)
  • Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF.
    The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
    Sci Rep. 2018 Nov 15;8(1):16913. doi: 10.1038/s41598-018-35277-8. (PubMed)
  • Gustafsson G, Lööv C, Persson E, Lázaro DF, Takeda S, Bergström J, Erlandsson A, Sehlin D, Balaj L, György B, Hallbeck M, Outeiro TF, Breakefield XO, Hyman BT, Ingelsson M.
    Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.
    Cell Mol Neurobiol. 2018 Nov;38(8):1539-1550. doi: 10.1007/s10571-018-0622-5. Epub 2018 Oct 4. (PubMed)
  • Rink WM, Thomas F.
    Decoration of Coiled-Coil Peptides with N-Cysteine Peptide Thioesters As Cyclic Peptide Precursors Using Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) Click Reaction.
    Org Lett. 2018 Nov 8. DOI: 10.1021/acs.orglett.8b03261 [Epub ahead of print] (PubMed)
  • Elliott SJ, Kaderavek P, Brown LJ, Sabba M, Glöggler S, O’Leary DJ, Brown RCD, Ferrage F, Levitt MH.
    Field-cycling long-lived-state NMR of 15N2 spin pairs.
    Mol. Phys. DOI: 10.1080/00268976.2018.1543906 (2018). ()
  • Fornasiero EF, Mandad S, Wildhagen H, Alevra M, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Sakib MS, Fard MK, Kirli K, Centeno TP, Vidal RO, Rahman RU, Benito E, Fischer A, Dennerlein S, Rehling P, Feussner I, Bonn S, Simons M, Urlaub H, Rizzoli SO.
    Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions.
    Nat Commun. 2018 Oct 12;9(1):4230. doi: 10.1038/s41467-018-06519-0. (PubMed)
  • Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfó E, Ventura S.
    Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
    Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486. doi: 10.1073/pnas.1804198115. Epub 2018 Sep 24. (PubMed)
  • Prasad V, Wasser Y, Hans F, Goswami A, Katona I, Outeiro TF, Kahle PJ, Schulz JB, Voigt A.
    Monitoring α-synuclein multimerization in vivo.
    FASEB J. 2018 Sep 25:fj201800148RRR. doi: 10.1096/fj.201800148RRR. [Epub ahead of print] (PubMed)
  • Chakrabarti R, Michanski S, Wichmann C.
    Vesicle sub-pool organization at inner hair cell ribbon synapses.
    (2018) EMBO Rep. 2018 Sep 10. pii: e44937. DOI:10.15252/embr.201744937 [Epub ahead of print] (PubMed)
  • Roser AE, Caldi Gomes L, Schünemann J, Maass F, Lingor P.
    Circulating miRNAs as Diagnostic Biomarkers for Parkinson’s Disease.
    Front Neurosci. 2018 Sep 5;12:625. doi: 10.3389/fnins.2018.00625. eCollection 2018. (PubMed)
  • Magalhães RSS, Popova B, Braus GH, Outeiro TF, Eleutherio ECA.
    The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.
    FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy066. (PubMed)
  • Hövener JB, Pravdivtsev AN, Kidd B, Bowers CR, Glöggler S, Kovtunov KV, Plaumann M, Katz-Brull R, Buckenmaier K, Jerschow A, Reineri F, Theis T, Shchepin RV, Wagner S, Bhattacharya P, Zacharias NM, Chekmenev EY.
    Parahydrogen-Based Hyperpolarization for Biomedicine.
    Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201711842. (PubMed)
  • Mann FA, Horlebein J, Meyer NF, Meyer D, Thomas F, Kruss S.
    Carbon Nanotubes Encapsulated in Coiled-Coil Peptide Barrels.
    Chem. Eur. J. 2018, DOI: 10.1002/chem.201800993. Cover feature (PubMed)
  • Mamone S, Glöggler S.
    Nuclear spin singlet states as magnetic on/off probes in self-assembling systems.
    Phys. Chem. Chem. Phys., 2018, DOI: 10.1039/C8CP04448A. (pubs.rsc)
  • Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF.
    Membrane binding, internalization, and sorting of alpha-synuclein in the cell.
    Acta Neuropathol Commun. 2018 Aug 14;6(1):79. doi: 10.1186/s40478-018-0578-1. (PubMed)
  • Rink WM, Thomas F.
    De novo designed α-helical coiled-coil peptides as scaffolds for chemical reactions.
    Chem. Eur. J. 2018, DOI: 10.1002/chem.201802849. (PubMed)
  • Paiva I, Jain G, Lázaro DF, Jerčić KG, Hentrich T, Kerimoglu C, Pinho R, Szegő ÈM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF.
    Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function.
    Neurobiol Dis. 2018 Aug 6;119:121-135. doi: 10.1016/j.nbd.2018.08.001. (PubMed)
  • Korchak S, Mamone S, Glöggler S.
    Over 50 % 1H and 13C Polarization for Generating Hyperpolarized Metabolites—A para‐Hydrogen Approach.
    ChemistryOpen. 2018, DOI: 10.1002/chem.201800086. (Wiley online library)
  • Truckenbrodt S, Maidorn M, Crzan D, Wildhagen H, Kabatas S, Rizzoli SO.
    X10 expansion microscopy enables 25-nm resolution on conventional microscopes.
    EMBO Rep. 2018 Jul 9. pii: e45836. doi: 10.15252/embr.201845836. (PubMed)
  • Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO.
    Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
    EMBO J. 2018 Aug 1;37(15). pii: e98044. doi: 10.15252/embj.201798044. Epub 2018 Jun 27. (PubMed)
  • Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V,Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.
    Age-related shift in LTD is dependent on neuronal adenosine A(2A) receptors interplay with mGluR5 and NMDA receptors.
    Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print] (PubMed)
  • McCormick J, Korchak S, Mamone S, Ertas YN, Liu Z, Verlinsky L, Wagner S, Glöggler S, Bouchard LS.
    More Than 12% Polarization and 20 Minutes Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water.
    Angew. Chem. Int. Ed. 2018, 57, 10692-10696. (PubMed)
  • Roser AE, Caldi Gomes L, Halder R, Jain G, Maass F, Tönges L, Tatenhorst L, Bähr M, Fischer A, Lingor P.
    miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.
    Mol Ther Nucleic Acids. 2018 Jun 1;11:9-22. doi: 10.1016/j.omtn.2018.01.005. Epub 2018 Feb 2. (PubMed)
  • Vaz RL, Outeiro TF, Ferreira JJ.
    Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review.
    Front Neurol. 2018 Jun 1;9:347. doi: 10.3389/fneur.2018.00347. eCollection 2018. (PubMed)
  • Korchak S, Yang S, Mamone S, Glöggler S.
    Pulsed Magnetic Resonance to Signal-Enhance Metabolites within Seconds by utilizing para-Hydrogen.
    ChemistryOpen. 2018 May 8;7(5):344-348. doi: 10.1002/open.201800024. eCollection 2018 May. (PubMed)
  • Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE,Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN.
    (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.
    Sci Rep. 2018 May 3;8(1):6965. doi: 10.1038/s41598-018-25118-z. (PubMed)
  • Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.
    The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.
    Mol Neurobiol. 2018 Apr 19. doi:10.1007/s12035-018-1084-y. (PubMed)
  • Groth MC, Rink WM, Meyer NF, Thomas F.
    Kinetic Studies on Strand Displacement in de novo Designed Parallel Heterodimeric Coiled Coils.
    Chem. Sci. 2018, 9, 4308–4316. (PubMed)
  • Biosa A, Outeiro TF, Bubacco L, Bisaglia M.
    Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View.
    Mol Neurobiol. 2018 Mar 28. doi: 10.1007/s12035-018-1025-9. [Epub ahead of print] Review. (PubMed)
  • Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO.
    Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.
    Biophys J. 2018 Mar 13;114(5):1036-1045. doi: 10.1016/j.bpj.2018.01.003. (PubMed)
  • Fourcade S, Outeiro TF, Pujol A.
    SIRT2 in age-related neurodegenerative disorders.
    Aging (Albany NY). 2018 Mar 3;10(3):295-296. doi:10.18632/aging/101397. (PubMed)
  • König A, Vicente Miranda H, Outeiro TF.
    Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease.
    J Parkinsons Dis. 2018;8(1):33-43. doi: 10.3233/JPD-171285. (PubMed)
  • Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung S, Gültas M, Maxeiner S, Neef A, Wichmann C, Strenzke N, Grabner C, Moser T.
    The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
    Elife. 2018 Jan 12;7. pii: e29275. doi: 10.7554/eLife.29275. (PubMed)
  • Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C,Meyer T.
    Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study.
    World J Biol Psychiatry. 2018 Jan 11:1-9. doi: 10.1080/15622975.2017.1417636. [Epub ahead of print] (PubMed)
  • Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.
    Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy.
    EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16. (PubMed)
  • Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.
    Guidelines and recommendations on yeast cell death nomenclature.
    Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review. (PubMed)

2017

  • Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Gonçalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltényi G, Borovecki F, Soreq H, Ferreira JJ, Outeiro TF.
    Correction: Gene Expression Differences in Peripheral Blood of Parkinson’s Disease Patients with Distinct Progression Profiles.
    PLoS One. 2017 Dec 28;12(12):e0190552. doi: 10.1371/journal.pone.0190552. eCollection 2017 (PubMed)
  • Bozek T, Blazekovic A, Perkovic MN, Jercic KG, Sustar A, Smircic-Duvnjak L, Outeiro TF, Pivac N, Borovecki F.
    The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus.
    Diabetol Metab Syndr. 2017 Dec 4;9:97. doi: 10.1186/s13098-017-0295-0. eCollection 2017. (PubMed)
  • Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al’Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA,Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.
    Building Bridges through Science.
    Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028. (PubMed)
  • Krinner S, Butola T, Jung S, Wichmann C, Moser T.
    RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.
    Front Cell Neurosci. 2017 Nov 2;11:334. doi: 10.3389/fncel.2017.00334. eCollection 2017. (PubMed)
  • Lemos V, de Oliveira RM, Naia L, Szegö É, Ramos E, Pinho S, Magro F, Cavadas C, Rego AC, Costa V, Outeiro TF, Gomes P.
    The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
    Hum Mol Genet. 2017 Nov 1;26(21):4105-4117. doi: 10.1093/hmg/ddx298. (PubMed)
  • Guedes LC, Chan RB, Gomes MA, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Carriço JA, Alcalay RN, Ferreira JJ, Outeiro TF, Miltenberger-Miltenyi G.
    Serum lipid alterations in GBA-associated Parkinson’s disease.
    Parkinsonism Relat Disord. 2017 Nov;44:58-65. doi: 10.1016/j.parkreldis.2017.08.026. Epub 2017 Sep 1. (PubMed)
  • López-León M, Outeiro TF, Goya RG.
    Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain.
    Ageing Res Rev. 2017 Nov;40:168-181. doi: 10.1016/j.arr.2017.09.002. Epub 2017 Sep 10. Review. (PubMed)
  • Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.
    α-synuclein interacts with PrP(C) to induce cognitive impairment through mGluR5 and NMDAR2B.
    Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25. (PubMed)
  • Butola T, Wichmann C, Moser T.
    Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.
    Front Synaptic Neurosci. 2017 Oct 25;9:14. doi: 10.3389/fnsyn.2017.00014. eCollection 2017. (PubMed)
  • Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF.
    Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease.
    Sci Rep. 2017 Oct 20;7(1):13713. doi: 10.1038/s41598-017-14175-5. (PubMed)
  • Roodveldt C, Outeiro TF, Braun JEA.
    Editorial: Molecular Chaperones and Neurodegeneration.
    Front Neurosci. 2017 Oct 11;11:565. doi: 10.3389/fnins.2017.00565. eCollection 2017. (PubMed)
  • Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.
    Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.
    Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260. (PubMed)
  • Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA.
    Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.
    Mol Neurobiol. 2018 Jun;55(6):5269-5281. doi: 10.1007/s12035-017-0755-4. Epub 2017 Sep 7. (PubMed)
  • Correia Guedes L, Reimão S, Paulino P, Nunes RG, Bouça-Machado R, Abreu D, Gonçalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, Campos J, Outeiro TF, Sampaio C, Bonifati V, Ferreira JJ.
    Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson’s disease.
    Mov Disord. 2017 Sep;32(9):1331-1333. doi: 10.1002/mds.27083. Epub 2017 Jul 7. (PubMed)
  • Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego ÉM, Kerimoglu C, Gerhardt E, Rego AC, Fischer A, Bonn S, Outeiro TF.
    Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.
    Hum Mol Genet. 2017 Jun 15;26(12):2231-2246. doi: 10.1093/hmg/ddx114. (PubMed)
  • Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.
    Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
    Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056. (PubMed)
  • de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.
    The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
    PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. (PubMed)
  • Gomes de Castro MA, Höbartner C, Opazo F.
    Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy.
    PLoS One. 2017 Feb 24;12(2):e0173050. doi: 10.1371/journal.pone.0173050. eCollection 2017. (PubMed)

2016

Maidorn M, Rizzoli SO, Opazo F.
Tools and limitations to study the molecular composition of synapses by fluorescence microscopy.
Biochem J. 2016 Oct 15;473(20):3385-3399. Review. (PubMed)

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